Bruun C, Bille J, Hansen K T, Kann J, Qvist V, Thylstrup A
Community Dent Oral Epidemiol. 1985 Dec;13(6):299-303. doi: 10.1111/j.1600-0528.1985.tb00460.x.
251 9-12-yr-old children completed a 3-yr, double-blind, clinical trial of two caries preventive fluoride programs. Caries increments and progression patterns were compared in two groups of children who rinsed every fortnight with a 0.2% NaF solution or received biannual topical applications with a fluoride varnish (Fluor-Protector). Clinically recorded mean DFS increments were 3.3 +/- 0.2 (SE) in the rinse group and 3.5 +/- 0.2 in the varnish group. In both groups nearly half of these increments were recorded in the occlusal surfaces of second molars. The mean incremental DFS recorded radiographically on approximal surfaces of posterior teeth were 1.1 +/- 0.2 and 1.5 +/- 0.2 in the rinse and varnish group, respectively. None of the inter-group differences were statistically significant (P greater than 0.05). Detailed analyses of the radiographic scores revealed a similar and extremely slow caries progression in the two study groups and they strengthened the conclusion of equal clinical efficacy of the two treatments. None of the fluoride programs had been able to change preestablished patterns of caries development among the children.
251名9至12岁的儿童完成了一项为期3年的两种预防龋齿氟化物方案的双盲临床试验。比较了两组儿童的龋齿增量和进展模式，一组儿童每两周用0.2%的氟化钠溶液漱口，另一组儿童每半年接受一次含氟涂料（氟保护漆）的局部应用。临床记录的平均DFS增量在漱口组为3.3±0.2（标准误），在涂料组为3.5±0.2。在两组中，这些增量近一半记录在第二磨牙的咬合面。在漱口组和涂料组中，后牙邻面放射成像记录的平均DFS增量分别为1.1±0.2和1.5±0.2。组间差异均无统计学意义（P>0.05）。对放射成像评分的详细分析显示，两个研究组的龋齿进展相似且极其缓慢，这强化了两种治疗临床疗效相同的结论。两种氟化物方案均未能改变儿童预先确定的龋齿发展模式。
