Recent progress in the 3D printing of microneedle patches for biomedical applications.

3D-printed microneedles (MNs) have emerged as a transformative technology in drug delivery, diagnostics, and cosmetics, providing a minimally invasive alternative to traditional methods. This review highlights the advancements in 3D printing technologies, including fused deposition modeling (FDM), digital light processing (DLP), and stereolithography (SLA), which enable the precise fabrication of MNs with customizable geometries and functionalities. The unique ability of MNs to penetrate the stratum corneum facilitates enhanced delivery of therapeutic agents, biosensing capabilities, and improved patient compliance. Recent innovations in MNs design, such as biomimetic structures and optimized geometries, have significantly improved their mechanical properties and drug delivery efficiency. Furthermore, integrating sensing elements within MNs enables real-time monitoring of biomarkers, paving the way for personalized medicine. Despite the promising applications, challenges remain, including regulatory considerations, material biocompatibility, and manufacturing scalability. This review discusses the current state of 3D-printed MNs, their diverse applications, and future directions. By addressing existing limitations and exploring novel materials and hybrid fabrication techniques, 3D-printed MNs have the potential to revolutionize healthcare delivery and improve patient outcomes.