Shanghai Innovation Center of TCM Health Service, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Beicai Community Health Service Center of Pudong New District, No. 271 Lianyuan Road, Shanghai, China.
BMC Oral Health. 2024 Aug 5;24(1):895. doi: 10.1186/s12903-024-04676-x.
The health of oral cavity is considered as an important indicator of aging. Oral microbiota is highly associated with the oral health, while the variation of oral microbiome in elderly population and characteristic microbes associated with aging remain unclear.
In this study, 130 elderly subjects were recruited and divided into 3 groups according to their age: Stage I group (65 ≤ years < 70), Stage II group (70 ≤ years < 75), and Stage III group (75 ≤ years < 80). Their physiological indices were analyzed with using Illumina MiSeq platform and the oral microbiome was determined by high-throughput sequencing.
Along with aging, the level of fasting blood glucose, systolic pressure and monocytes are significantly increased. No significant difference was detected on the whole structure of the oral microbiome among groups. While using Metastats and Spearman's correlation analysis, specific bacteria were identified as potential age- or health index-related bacterial genera including Fusobacterium, Parvimonas, Porphyromonas, Aminobacter, Collinsella, Clostridium and Acinetobacter.
Our study revealed that the composition structure of salivary microbiota in elderly population was relatively stable while specific bacteria were correlated with age and health status, which is promising to be served as health indicators of the elderly after further exploration.
口腔健康被认为是衰老的一个重要指标。口腔微生物群与口腔健康高度相关，而老年人的口腔微生物组的变化和与衰老相关的特征微生物仍不清楚。
本研究招募了 130 名老年人，并根据年龄分为 3 组：I 期组（65≤岁<70）、II 期组（70≤岁<75）和 III 期组（75≤岁<80）。使用 Illumina MiSeq 平台分析他们的生理指标，通过高通量测序确定口腔微生物组。
随着年龄的增长，空腹血糖、收缩压和单核细胞水平显著升高。各组口腔微生物组的整体结构无明显差异。使用 Metastats 和 Spearman 相关性分析，鉴定出特定细菌为潜在的与年龄或健康指标相关的细菌属，包括梭杆菌属、卟啉单胞菌属、普雷沃氏菌属、阿米诺杆菌属、柯林斯菌属、梭菌属和不动杆菌属。
我们的研究表明，老年人口腔微生物群的组成结构相对稳定，而特定细菌与年龄和健康状况相关，这有望在进一步探索后成为老年人的健康指标。
