Yang Yaohua, Cai Qiuyin, Zheng Wei, Steinwandel Mark, Blot William J, Shu Xiao-Ou, Long Jirong
Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, USA.
J Oral Microbiol. 2019 Aug 9;11(1):1650597. doi: 10.1080/20002297.2019.1650597. eCollection 2019.
Few studies have evaluated the relationship of oral microbiome with obesity. We investigated the oral microbiome among 647 obese and 969 non-obese individuals from the Southern Community Cohort Study, through gene sequencing in mouth rinse samples. We first investigated 16 taxa in two probiotic genera, and . Among them, eight showed nominal associations with obesity ( < 0.05). Especially, (odds ratio [OR] = 0.67, 95% confidence interval [CI]:0.54, 0.83) and (OR = 0.57, 95% CI: 0.45, 0.73) were significantly associated with decreased obesity prevalence with false-discovery rate (FDR)-corrected of 0.01 and 5.41 × 10, respectively. Multiple other bacterial taxa were also significantly associated with obesity prevalence at FDR-corrected < 0.05. Among them, five in and two respectively in and were significantly associated with increased obesity prevalence. Significant associations with decreased obesity prevalence were observed for two taxa respectively in and . Most of these taxa were associated with body mass index at study enrollment and weight gain during adulthood. Also, most of these associations were observed in both European- and African-Americans. Our findings indicate that multiple oral bacterial taxa, including several probiotic taxa, were significantly associated with obesity.
很少有研究评估口腔微生物群与肥胖之间的关系。我们通过对南方社区队列研究中647名肥胖个体和969名非肥胖个体的漱口水样本进行基因测序，调查了他们的口腔微生物群。我们首先研究了两个益生菌属中的16个分类单元。其中，有8个与肥胖存在名义上的关联（P<0.05）。特别是，嗜酸乳杆菌（优势比[OR]=0.67，95%置信区间[CI]：0.54，0.83）和双歧杆菌（OR=0.57，95%CI：0.45，0.73）分别在错误发现率（FDR）校正后P值为0.01和5.41×10时，与肥胖患病率降低显著相关。在FDR校正P<0.05时，多个其他细菌分类单元也与肥胖患病率显著相关。其中，嗜酸乳杆菌属中有5个，罗氏菌属和孪生球菌属中分别有2个与肥胖患病率增加显著相关。在嗜胆菌属和孪生球菌属中，分别有两个分类单元与肥胖患病率降低存在显著关联。这些分类单元中的大多数与研究入组时的体重指数以及成年期体重增加有关。此外，这些关联在欧洲裔和非裔美国人中均有观察到。我们的研究结果表明，包括几种益生菌分类单元在内的多种口腔细菌分类单元与肥胖显著相关。
