诱变剂2-氨基-6-甲基二吡啶并[1,2-a:3',2'-d]咪唑的代谢活化。2-羟基氨基-6-甲基二吡啶并[1,2-a:3',2'-d]咪唑的鉴定及其与DNA的反应。 - Suppr

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超能文献

Metabolic activation of a mutagen, 2-amino-6-methyldipyrido-[1,2-a:3',2'-d]imidazole. Identification of 2-hydroxyamino-6-methyldipyrido [1,2-a:3',2'-d]imidazole and its reaction with DNA.

作者信息

Hashimoto Y, Shudo K, Okamoto T

出版信息

Biochem Biophys Res Commun. 1980 Feb 12;92(3):971-6. doi: 10.1016/0006-291x(80)90797-4.

DOI:10.1016/0006-291x(80)90797-4

PMID:7362617

Abstract

摘要

相似文献

Metabolic activation of a mutagen, 2-amino-6-methyldipyrido-[1,2-a:3',2'-d]imidazole. Identification of 2-hydroxyamino-6-methyldipyrido [1,2-a:3',2'-d]imidazole and its reaction with DNA.诱变剂2-氨基-6-甲基二吡啶并[1,2-a:3',2'-d]咪唑的代谢活化。2-羟基氨基-6-甲基二吡啶并[1,2-a:3',2'-d]咪唑的鉴定及其与DNA的反应。

Biochem Biophys Res Commun. 1980 Feb 12;92(3):971-6. doi: 10.1016/0006-291x(80)90797-4.

Reactions of potent mutagens, 3-amino-1-methyl-5H-pyrido[4,3-b]indole (Trp-P-2) and 2-amino-6-methyl-dipyrido[1,2-a:3',2'-d]imidazole (Glu-P-1) with nucleic acid.强诱变剂3-氨基-1-甲基-5H-吡啶并[4,3-b]吲哚（Trp-P-2）和2-氨基-6-甲基-二吡啶并[1,2-a:3',2'-d]咪唑（Glu-P-1）与核酸的反应。

Nucleic Acids Symp Ser. 1980(8):s109-12.

Activation of a mutagen, 3-amino-1-methyl-5H-pyrido[4,3-b]indole. Identification of 3-hydroxyamino-1-methyl-5H-pyrido[4,3-b]indole and its reacion with DNA.诱变剂3-氨基-1-甲基-5H-吡啶并[4,3-b]吲哚的激活。3-羟基氨基-1-甲基-5H-吡啶并[4,3-b]吲哚的鉴定及其与DNA的反应。

Biochem Biophys Res Commun. 1980 Sep 16;96(1):355-62. doi: 10.1016/0006-291x(80)91222-x.

Immunological titration of 3-N-acetyl-hydroxyamino-4,6-dimethyldipyrido(1,2-a:3',2'-d) imidazole-rat liver DNA adducts.3-N-乙酰基-羟基氨基-4,6-二甲基二吡啶并(1,2-a:3',2'-d)咪唑-大鼠肝脏DNA加合物的免疫滴定

Carcinogenesis. 1985 Jun;6(6):937-9. doi: 10.1093/carcin/6.6.937.

Chemical modification of DNA with muta-carcinogens. I. 3-Amino-1-methyl-5H-pyrido[4,3-b]indole and 2-amino-6-methyldipyrido[1,2-a:3',2'-d]imidazole: metabolic activation and structure of the DNA adducts.用诱变致癌物对DNA进行化学修饰。I. 3-氨基-1-甲基-5H-吡啶并[4,3-b]吲哚和2-氨基-6-甲基二吡啶并[1,2-a:3',2'-d]咪唑：DNA加合物的代谢活化与结构

Environ Health Perspect. 1985 Oct;62:209-14. doi: 10.1289/ehp.8562209.

Modification of nucleic acids with muta-carcinogenic heteroaromatic amines in vivo. Identification of modified bases in DNA extracted from rats injected with 3-amino-1-methyl-5H-pyrido[4,3-b]indole and 2-amino-6-methyldipyrido[1,2-a3:3',2'-d]imidazole.体内用诱变致癌杂环胺对核酸进行修饰。从注射了3-氨基-1-甲基-5H-吡啶并[4,3-b]吲哚和2-氨基-6-甲基二吡啶并[1,2-a:3',2'-d]咪唑的大鼠中提取的DNA中修饰碱基的鉴定。

Mutat Res. 1982 Aug;105(1-2):9-13. doi: 10.1016/0165-7992(82)90200-7.

N-acetyl derivative as the major active metabolite of 2-amino-6-methyldipyrido[1,2-a:3',2'-d]imidazole in rat bile.N-乙酰衍生物作为2-氨基-6-甲基二吡啶并[1,2-a:3',2'-d]咪唑在大鼠胆汁中的主要活性代谢物。

Mutat Res. 1986 Sep;175(1):23-8. doi: 10.1016/0165-7992(86)90140-5.

Metabolic formation, synthesis and genotoxicity of the N-hydroxy derivative of the food mutagen 2-amino-1-methyl-6-phenylimidazo (4,5-b) pyridine (PhIP).

Mutagenesis. 1991 Jan;6(1):93-8. doi: 10.1093/mutage/6.1.93.

Syntheses of hydroxyamino, nitroso and nitro derivatives of Trp-P-2 and Glu-P-1, amino acid pyrolysate mutagens, and their direct mutagenicities towards Salmonella typhimurium TA98 and TA98NR.

Carcinogenesis. 1983 Dec;4(12):1547-50. doi: 10.1093/carcin/4.12.1547.

In vitro reaction of hydroxyamino derivatives of MeIQx, Glu-P-1 and Trp-P-1 with DNA: 32P-postlabelling analysis of DNA adducts formed in vivo by the parent amines and in vitro by their hydroxyamino derivatives.

Mutagenesis. 1988 Nov;3(6):515-20. doi: 10.1093/mutage/3.6.515.

引用本文的文献

Environ Health Perspect. 1985 Oct;62:209-14. doi: 10.1289/ehp.8562209.

Chemical modification of DNA with muta-carcinogens. II. Base sequence-specific binding to DNA of 2-amino-6-methyl-dipyrido[1,2-a:3',2'-d]imidazole (Glu-P-1).用诱变致癌物对DNA进行化学修饰。II. 2-氨基-6-甲基-二吡啶并[1,2-a:3',2'-d]咪唑（Glu-P-1）与DNA的碱基序列特异性结合

Environ Health Perspect. 1985 Oct;62:215-8. doi: 10.1289/ehp.8562215.

Metabolic aspects of pyrolysis mutagens in food.食品中热解诱变剂的代谢方面

Environ Health Perspect. 1986 Aug;67:105-9. doi: 10.1289/ehp.8667105.

Past, present, and future of mutagens in cooked foods.熟食中诱变剂的过去、现在与未来。

Environ Health Perspect. 1986 Aug;67:5-10. doi: 10.1289/ehp.86675.

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