Sam Napoleon Bellua, Tabiri Stephen, Amofa Ebenezer
Department of Medical Research and Innovation School of Medicine University for Development Studies, Tamale, Northern Region, Ghana.
Department of Surgery School of Medicine University for Development Studies, Tamale, Northern Region, Ghana.
Autoimmune Dis. 2024 Jul 20;2024:9948612. doi: 10.1155/2024/9948612. eCollection 2024.
Most published results have revealed variations in the association of serum/plasma levels of malondialdehyde (MDA), apolipoprotein B (ApoB), and oxidized low-density lipoprotein (OxLDL) and systemic lupus erythematosus (SLE). This study was performed to establish MDA, ApoB, and OxLDL levels in systemic lupus erythematosus (SLE) patients. Electronic databases were searched for the included articles up to 27th February 2023. The meta-analysis included 48 articles with 2358 SLE patients and 2126 healthy controls considered for MDA, ApoB, and OxLDL levels. There were significantly higher MDA, ApoB, and OxLDL levels in SLE patients than those in the control groups. Subgroup analysis indicated that European/American SLE patients and patients of both ages <36 and ≥36 exhibited higher MDA, ApoB, and OxLDL levels. Arab and Asian SLE patients had higher ApoB and MDA/OxLDL levels. African SLE patients recorded higher OxLDL levels than the control groups. SLE patients with a body mass index (BMI) of ≥23 and a disease duration of <10 recorded significantly higher MDA, ApoB, and OxLDL levels. Patients with systemic lupus erythematosus disease activity index (SLEDAI) ≥8 of SLE had higher MDA and ApoB levels, whereas SLE patients with SLEDAI <8 showed significantly higher ApoB levels. Patients with BMI <23 of SLE had higher MDA and OxLDL levels. This study established significantly higher MDA, ApoB, and OxLDL levels in SLE patients, suggesting a possible role of MDA, ApoB, and OxLDL in the disease.
大多数已发表的研究结果显示，血清/血浆中丙二醛（MDA）、载脂蛋白B（ApoB）和氧化型低密度脂蛋白（OxLDL）水平与系统性红斑狼疮（SLE）之间的关联存在差异。本研究旨在确定系统性红斑狼疮（SLE）患者的MDA、ApoB和OxLDL水平。检索了电子数据库中截至2023年2月27日的相关文章。荟萃分析纳入了48篇文章，共2358例SLE患者和2126例健康对照，对其MDA、ApoB和OxLDL水平进行了分析。SLE患者的MDA、ApoB和OxLDL水平显著高于对照组。亚组分析表明，欧美SLE患者以及年龄<36岁和≥36岁的患者MDA、ApoB和OxLDL水平较高。阿拉伯和亚洲SLE患者的ApoB以及MDA/OxLDL水平较高。非洲SLE患者的OxLDL水平高于对照组。体重指数（BMI）≥23且病程<10年的SLE患者MDA、ApoB和OxLDL水平显著更高。系统性红斑狼疮疾病活动指数（SLEDAI）≥8的SLE患者MDA和ApoB水平较高，而SLEDAI<8的SLE患者ApoB水平显著更高。BMI<23的SLE患者MDA和OxLDL水平较高。本研究证实SLE患者的MDA、ApoB和OxLDL水平显著更高，提示MDA、ApoB和OxLDL在该疾病中可能发挥作用。
