系统性红斑狼疮患者循环抗氧化剂水平：系统评价和荟萃分析。
Circulating antioxidant levels in systemic lupus erythematosus patients: a systematic review and meta-analysis.
机构信息
Department of Epidemiology & Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui, PR China.
Anhui Province Key Laboratory of Major Autoimmune Diseases, 81 Meishan Road, Hefei, Anhui, PR China.
出版信息
Biomark Med. 2019 Sep;13(13):1137-1152. doi: 10.2217/bmm-2019-0034. Epub 2019 Sep 2.
To derive a precise estimation on plasma/serum level of SOD, GPx, CAT and GSH levels in systemic lupus erythematosus (SLE) patients. A total of 36 articles from electronic databases were finally included with 1120 SLE patients and 1024 healthy controls considered for antioxidant levels. The levels of CAT and GSH were significantly lower, while SOD and GPx levels were slightly lower in patients with SLE compared with healthy controls. Subgroup analysis indicated that Arabs, ages ≥40 and SLE diseases activity index <6 had a significant association of SOD and CAT levels with SLE patients. The results demonstrated a significant lower CAT and GSH levels and also revealed no significant difference for SOD and GPx levels in SLE patients.
为了对系统性红斑狼疮（SLE）患者的血浆/血清中超氧化物歧化酶（SOD）、谷胱甘肽过氧化物酶（GPx）、过氧化氢酶（CAT）和谷胱甘肽（GSH）水平进行精确估计。最终纳入了来自电子数据库的 36 篇文章，其中包括 1120 名 SLE 患者和 1024 名健康对照者，用于评估抗氧化剂水平。与健康对照组相比，SLE 患者的 CAT 和 GSH 水平显著降低，而 SOD 和 GPx 水平略低。亚组分析表明，阿拉伯人、年龄≥40 岁和 SLE 疾病活动指数＜6 的患者的 SOD 和 CAT 水平与 SLE 患者显著相关。结果表明，SLE 患者的 CAT 和 GSH 水平显著降低，而 SOD 和 GPx 水平则无显著差异。
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