Department of Natural Science, Middlesex University, Hendon, London, UK.
Pathology Department, Faculty of Medicine, Tanta University, Tanta, Egypt.
Clin Exp Med. 2024 Aug 6;24(1):178. doi: 10.1007/s10238-024-01446-5.
This review explores the pivotal role of angiogenesis in breast cancer progression and treatment. It covers biomarkers, imaging techniques, therapeutic approaches, resistance mechanisms, and clinical implications. Key topics include Vascular Endothelial Growth Factors, angiopoietins, microRNA signatures, and circulating endothelial cells as biomarkers, along with Magnetic Resonance Imaging, Computed Tomography Angiography, Ultrasound, and Positron Emission Tomography for imaging. Therapeutic strategies targeting VEGF, tyrosine kinase inhibitors, and the intersection of angiogenesis with immunotherapy are discussed. Challenges such as resistance mechanisms and personalized medicine approaches are addressed. Clinical implications, prognostic value, and the future direction of angiogenesis-targeted therapies are highlighted. The article concludes with reflections on the transformative potential of understanding angiogenesis.
这篇综述探讨了血管生成在乳腺癌进展和治疗中的关键作用。它涵盖了生物标志物、成像技术、治疗方法、耐药机制以及临床意义。主要内容包括血管内皮生长因子、血管生成素、微 RNA 特征和循环内皮细胞作为生物标志物，以及磁共振成像、计算机断层血管造影、超声和正电子发射断层扫描的成像方法。还讨论了针对血管内皮生长因子、酪氨酸激酶抑制剂的治疗策略，以及血管生成与免疫治疗的交叉点。探讨了耐药机制和个性化医学方法等挑战。强调了临床意义、预后价值以及针对血管生成的治疗的未来方向。文章最后对理解血管生成的变革潜力进行了反思。
