Zhang Xiao, Zhang Yan, Zhuang Zhe, Zhao Chan, Gao Fei, Dai Rong-Ping, Yu Wei-Hong, Chen You-Xin, Zhang Wei, Zhang Mei-Fen
From the Department of Ophthalmology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences (X.Z., C.Z., F.G., R.-P.D., W.-H.Y., Y.-X.C., M.-F.Z.); Key Laboratory of Ocular Fundus Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College (X.Z., C.Z., F.G., R.-P.D., W.-H.Y., Y.-X.C., M.-F.Z.).
and Department of Hematology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences (Y.Z., Z.Z., W.Z.), Beijing, China.
Am J Ophthalmol. 2023 Feb;246:242-250. doi: 10.1016/j.ajo.2022.10.009. Epub 2022 Oct 28.
To analyze the correlation between cerebrospinal fluid (CSF) interleukin-10 (IL-10) levels and the clinical characteristics in patients with vitreoretinal lymphoma (VRL).
Retrospective observational case series.
Forty-one patients were diagnosed as VRL and underwent lumbar puncture for CSF examination. Aqueous humor cytokine detection, vitreous cytopathologic analysis, monoclonal gene rearrangement, and flow cytometry were performed. The CSF was assessed through biochemical and cytologic examination, flow cytometry, and cytokine detection.
The median levels of aqueous humor IL-10 and IL-6 were 415.0 and 40.7 pg/mL. The median CSF levels of IL-10 and IL-6 were 35.7 and 3.5 pg/mL, respectively. IL-10 levels in CSF were higher than normal in 37 patients (90.2%) and higher in patients with intracranial lesions. The level of CSF IL-10 decreased after systemic treatment, and it rose before intracranial lesion onset or recurrence. The level of IL-10 in CSF was related to the duration of ocular symptoms, but was not related to the level of IL-10 in aqueous humor. There was no significant difference in CSF IL-10 levels between patients with and without anterior chamber inflammation or retinal lesions. In eyes with recurrent vitreoretinal lymphoma, the level of IL-10 in aqueous humor increased significantly, but there was no corresponding increase in the level of IL-10 in CSF.
CSF IL-10 is a potentially important biomarker in VRL, especially in the monitoring of intracranial lesions.
分析玻璃体视网膜淋巴瘤（VRL）患者脑脊液（CSF）白细胞介素-10（IL-10）水平与临床特征之间的相关性。
回顾性观察病例系列。
41例患者被诊断为VRL并接受腰椎穿刺进行脑脊液检查。进行了房水细胞因子检测、玻璃体细胞病理学分析、单克隆基因重排和流式细胞术。通过生化和细胞学检查、流式细胞术和细胞因子检测对脑脊液进行评估。
房水IL-10和IL-6的中位数水平分别为415.0和40.7 pg/mL。脑脊液中IL-10和IL-6的中位数水平分别为35.7和3.5 pg/mL。37例患者（90.2%）脑脊液中的IL-10水平高于正常，颅内病变患者的水平更高。全身治疗后脑脊液中IL-10水平下降，在颅内病变发作或复发前升高。脑脊液中IL-10水平与眼部症状持续时间有关，但与房水中IL-10水平无关。有无前房炎症或视网膜病变的患者脑脊液IL-10水平无显著差异。在复发性玻璃体视网膜淋巴瘤患者的眼中，房水中IL-10水平显著升高，但脑脊液中IL-10水平没有相应升高。
脑脊液IL-10是VRL中一种潜在的重要生物标志物，尤其是在颅内病变的监测中。
