Department of Hepatobiliary and Pancreatic Surgery, Department of Oncology, The Affiliated Hospital of Qingdao University, Qingdao Cancer Institute, Qingdao, Shandong 266000, China.
Zhejiang Provincial Key Laboratory of Pancreatic Disease, The First Affiliated Hospital and Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310029, China; Cancer Center, Zhejiang University, Hangzhou, Zhejiang 310029, China; Institute of Fundamental and Transdisciplinary Research, Zhejiang University, Hangzhou, Zhejiang 310029, China.
Cell Metab. 2024 Aug 6;36(8):1637-1639. doi: 10.1016/j.cmet.2024.06.015.
In this issue of Cell Metabolism, Li et al. report that the highly expressed aldehyde dehydrogenase 1 family member A3 interacts with pyruvate kinase M2 (PKM2) in glioblastoma cells. Consequently, PKM2 tetramerization and activation promote lactate production, leading to the lactylation and nuclear translocation of XRCC1 for DNA damage repair and therapeutic resistance.
在本期《细胞代谢》中，Li 等人报道称，高表达的醛脱氢酶 1 家族成员 A3 在神经胶质瘤细胞中与丙酮酸激酶 M2（PKM2）相互作用。结果，PKM2 四聚体化和激活促进乳酸生成，导致 XRCC1 的乳酰化和核转位，以进行 DNA 损伤修复和治疗抵抗。
