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Integrating radiosensitivity index and triple-negative breast cancer subtypes reveals SERPINB5 as a radioresistance biomarker in triple-negative breast cancer.

作者信息

Rao Xinxin, Wang Xuanyi, He Chao, Jiang YiZhou, Shao ZhiMing, Feng Yan, Zhou Jundong, Guo Xiaomao, Chen Xingxing

机构信息

Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Shanghai, China.

Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.

出版信息

Clin Transl Med. 2024 Aug;14(8):e1787. doi: 10.1002/ctm2.1787.

DOI:10.1002/ctm2.1787
PMID:39113221
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11306282/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8fd0/11306282/b0f01db97372/CTM2-14-e1787-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8fd0/11306282/6ebb99e9a1c1/CTM2-14-e1787-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8fd0/11306282/fa2d0adec3db/CTM2-14-e1787-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8fd0/11306282/f17170b21aa0/CTM2-14-e1787-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8fd0/11306282/b0f01db97372/CTM2-14-e1787-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8fd0/11306282/6ebb99e9a1c1/CTM2-14-e1787-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8fd0/11306282/fa2d0adec3db/CTM2-14-e1787-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8fd0/11306282/f17170b21aa0/CTM2-14-e1787-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8fd0/11306282/b0f01db97372/CTM2-14-e1787-g002.jpg

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Integrating radiosensitivity index and triple-negative breast cancer subtypes reveals SERPINB5 as a radioresistance biomarker in triple-negative breast cancer.整合放射敏感性指数和三阴性乳腺癌亚型显示，丝氨酸蛋白酶抑制剂B5（SERPINB5）是三阴性乳腺癌的放射抗性生物标志物。
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本文引用的文献

1
Role of cytoplasmic localization of maspin in promoting cell invasion in breast cancer with aggressive phenotype.Maspin 细胞质定位在具有侵袭表型的侵袭性乳腺癌中促进细胞侵袭的作用。
Sci Rep. 2021 May 31;11(1):11321. doi: 10.1038/s41598-021-90887-z.
2
TRIM21-SERPINB5 aids GMPS repression to protect nasopharyngeal carcinoma cells from radiation-induced apoptosis.TRIM21-SERPINB5 辅助 GMPS 抑制以保护鼻咽癌细胞免受辐射诱导的细胞凋亡。
J Biomed Sci. 2020 Jan 31;27(1):30. doi: 10.1186/s12929-020-0625-7.
3
Using the Radiosensitivity Index (RSI) to Predict Pelvic Failure in Endometrial Cancer Treated With Adjuvant Radiation Therapy.
使用辐射敏感度指数（RSI）预测接受辅助放疗的子宫内膜癌患者的盆骨失败。
Int J Radiat Oncol Biol Phys. 2020 Mar 1;106(3):496-502. doi: 10.1016/j.ijrobp.2019.11.013. Epub 2019 Nov 20.
4
Genomic and Transcriptomic Landscape of Triple-Negative Breast Cancers: Subtypes and Treatment Strategies.三阴性乳腺癌的基因组和转录组全景：亚型和治疗策略。
Cancer Cell. 2019 Mar 18;35(3):428-440.e5. doi: 10.1016/j.ccell.2019.02.001. Epub 2019 Mar 7.
5
Identification and validation of single-sample breast cancer radiosensitivity gene expression predictors.单样本乳腺癌放射敏感性基因表达预测因子的鉴定和验证。
Breast Cancer Res. 2018 Jul 4;20(1):64. doi: 10.1186/s13058-018-0978-y.
6
Tumour radiosensitivity is associated with immune activation in solid tumours.实体瘤中的肿瘤放射敏感性与免疫激活相关。
Eur J Cancer. 2017 Oct;84:304-314. doi: 10.1016/j.ejca.2017.08.001. Epub 2017 Aug 29.
7
Comprehensive transcriptome analysis identifies novel molecular subtypes and subtype-specific RNAs of triple-negative breast cancer.综合转录组分析确定了三阴性乳腺癌的新型分子亚型和亚型特异性RNA。
Breast Cancer Res. 2016 Mar 15;18(1):33. doi: 10.1186/s13058-016-0690-8.
8
Validation of a radiosensitivity molecular signature in breast cancer.乳腺癌放射敏感性分子特征的验证。
Clin Cancer Res. 2012 Sep 15;18(18):5134-43. doi: 10.1158/1078-0432.CCR-12-0891. Epub 2012 Jul 25.
9
HDAC1 inhibition by maspin abrogates epigenetic silencing of glutathione S-transferase pi in prostate carcinoma cells.Maspin 通过抑制组蛋白去乙酰化酶 1 消除前列腺癌细胞中谷胱甘肽 S-转移酶 pi 的表观遗传沉默。
Mol Cancer Res. 2011 Jun;9(6):733-45. doi: 10.1158/1541-7786.MCR-10-0505. Epub 2011 May 26.
10
Endogenous inhibition of histone deacetylase 1 by tumor-suppressive maspin.肿瘤抑制蛋白maspin对组蛋白去乙酰化酶1的内源性抑制作用。
Cancer Res. 2006 Sep 15;66(18):9323-9. doi: 10.1158/0008-5472.CAN-06-1578.