The University of Queensland Diamantina Institute, Translational Research Institute, Woolloongabba 4102, QLD, Australia.
J Dermatol Sci. 2018 Jan;89(1):3-10. doi: 10.1016/j.jdermsci.2017.10.008. Epub 2017 Oct 26.
The skin, thought initially to protect the body passively from pathogenic organisms and other environmental insults, is now recognised additionally as a sophisticated immune organ that actively regulates local immunity. Studies linking local innate and adaptive immunity to skin health and disease have revealed a complex network of cell communication and cytokine signalling. Here, we review the last 10 years of literature on this topic, and its relevance to skin immunity.
皮肤最初被认为是被动保护身体免受病原体和其他环境侵害的器官，而现在被认为是一个复杂的免疫器官，能够主动调节局部免疫。将局部先天和适应性免疫与皮肤健康和疾病联系起来的研究揭示了细胞通讯和细胞因子信号的复杂网络。在这里，我们回顾了过去 10 年关于这个主题的文献，以及它与皮肤免疫的相关性。
