Wu Xiang'an, Cao Jingying, Wan Xueshuai, Du Shunda
Department of Liver Surgery, Peking Union Medical College Hospital, PUMC and Chinese Academy of Medical Sciences, Dongcheng, Beijing, 100730, China.
Zunyi Medical University, Zun Yi, Guizhou, 563000, China.
Cell Death Discov. 2024 Aug 8;10(1):356. doi: 10.1038/s41420-024-02116-x.
Hepatocellular Carcinoma (HCC), the most common primary liver cancer, ranks as the third most common cause of cancer-related deaths globally. A deeper understanding of the cell death mechanisms in HCC is essential for developing more effective treatment strategies. This review explores programmed cell death (PCD) pathways involved in HCC, including apoptosis, necroptosis, pyroptosis, ferroptosis, and immunogenic cell death (ICD). These mechanisms trigger specific cell death cascades that influence the development and progression of HCC. Although multiple PCD pathways are involved in HCC, shared cellular factors suggest a possible interplay between the different forms of cell death. However, the exact roles of different cell death pathways in HCC and which cell death pathway plays a major role remain unclear. This review also highlights how disruptions in cell death pathways are related to drug resistance in cancer therapy, promoting a combined approach of cell death induction and anti-tumor treatment to enhance therapeutic efficacy. Further research is required to unravel the complex interplay between cell death modalities in HCC, which may lead to innovative therapeutic breakthroughs.
肝细胞癌（HCC）是最常见的原发性肝癌，在全球癌症相关死亡原因中排名第三。深入了解HCC中的细胞死亡机制对于制定更有效的治疗策略至关重要。本综述探讨了参与HCC的程序性细胞死亡（PCD）途径，包括凋亡、坏死性凋亡、焦亡、铁死亡和免疫原性细胞死亡（ICD）。这些机制触发特定的细胞死亡级联反应，影响HCC的发生和发展。虽然多种PCD途径参与了HCC，但共同的细胞因子表明不同形式的细胞死亡之间可能存在相互作用。然而，不同细胞死亡途径在HCC中的确切作用以及哪种细胞死亡途径起主要作用仍不清楚。本综述还强调了细胞死亡途径的破坏与癌症治疗中的耐药性之间的关系，提倡采用诱导细胞死亡和抗肿瘤治疗相结合的方法来提高治疗效果。需要进一步研究来阐明HCC中细胞死亡方式之间的复杂相互作用，这可能会带来创新性的治疗突破。
