Anvarifard Mohammad K, Orouji Ali A
Department of Engineering Sciences, Faculty of Technology and Engineering, East of Guilan, University of Guilan, Rudsar-Vajargah, Iran.
Department of Electrical and Computer Engineering, Semnan University, Semnan, Iran.
Sci Rep. 2024 Aug 8;14(1):18395. doi: 10.1038/s41598-024-69383-7.
For the first time, a new configuration of label-free junctionless semiconductor device is proposed to boost sensitivity in the identification of biomolecule specifies. Instead of creating the nanocavity inside the gate oxide, the nanocavity is created in the channel region which is very useful for the SOI junctionless technology based biodevice having a high current in all operating modes. For better control of the conduction mechanism, a hole trench is created under the channel region just inside the buried oxide. This will help to modulate the energy bands terminating in enhancing the sensing performance. Unlike the conventional biosensors needing a large-scale gate oxide thickness for trapping the biomolecules, the proposed biosensor can work for very low gate oxide thickness. The different biomolecules such as Biotin, Protein A, Bacteriophage T7, and Apomyoglobin have been utilized as targeted biomolecules for evaluating the sensitivity. Comparing the proposed biosensor with the conventional and other biosensors showed an enhanced sensing performance. Practical related issues during the process of sensing in terms of fill factor percentage, steric hindrance of biomolecules, and the charges of biomolecules have been focused in the recommended biodevice. All the results exhibited high superiority of performance of the suggested biodevice as compared to the conventional biosensor.
首次提出了一种无标记无结半导体器件的新配置,以提高生物分子特异性识别的灵敏度。纳米腔不是在栅氧化层内部创建,而是在沟道区域创建,这对于基于绝缘体上硅(SOI)无结技术且在所有工作模式下都具有高电流的生物器件非常有用。为了更好地控制传导机制,在掩埋氧化物内部的沟道区域下方创建了一个空穴沟槽。这将有助于调制能带,从而提高传感性能。与需要较大栅氧化层厚度来捕获生物分子的传统生物传感器不同,所提出的生物传感器在非常低的栅氧化层厚度下就能工作。已将不同的生物分子,如生物素、蛋白A、噬菌体T7和脱辅基肌红蛋白用作目标生物分子来评估灵敏度。将所提出的生物传感器与传统生物传感器及其他生物传感器进行比较,结果显示其传感性能有所增强。在推荐的生物器件中,已关注了传感过程中与填充因子百分比、生物分子的空间位阻以及生物分子电荷相关的实际问题。与传统生物传感器相比,所有结果都显示出所建议生物器件的性能具有高度优越性。