用于胃癌诊断的唾液生物标志物：一项系统综述。
Salivary biomarkers for the diagnosis of gastric cancer: a systematic review.
作者信息
Zúñiga-Pérez Natalia, Muñoz-Navarro Humberto, Rivera César
机构信息
Oral and Maxillofacial Histopathology Laboratory, Department of Stomatology, Faculty of Dentistry, Universidad de Talca. Talca, Chile.
出版信息
Rev Cient Odontol (Lima). 2024 Jun 27;12(2):e199. doi: 10.21142/2523-2754-1202-2024-199. eCollection 2024 Apr-Jun.
BACKGROUND
Recent advancements reveal saliva as a crucial source of diagnostic biomarkers for various diseases, notably gastric cancer. This systematic review evaluates these biomarkers, emphasizing their clinical applicability and potential in early detection.
METHODS
An extensive electronic search was conducted across PubMed/MEDLINE, Scopus, and Web of Science to identify relevant studies. Salivary biomarkers were analyzed as independent variables, with gastric cancer as the dependent variable. The study adhered to a protocol registered with PROSPERO (CRD42021259519).
RESULTS
Our analysis identified a range of biomarkers, highlighting three proteins - cystatin-B (CSTB), triosephosphate isomerase (TPI1), and deleted in malignant brain tumors 1 protein (DMBT1) - as particularly accurate for gastric cancer diagnosis.
CONCLUSIONS
Salivary biomarkers hold substantial promise for the early detection of gastric cancer. Future research should aim to refine study design and validation for enhancing the quality and applicability of these biomarkers.
背景
最近的进展表明，唾液是各种疾病（尤其是胃癌）诊断生物标志物的重要来源。本系统评价评估了这些生物标志物，强调了它们在早期检测中的临床适用性和潜力。
方法
在PubMed/MEDLINE、Scopus和Web of Science上进行了广泛的电子检索，以确定相关研究。唾液生物标志物作为自变量进行分析，胃癌作为因变量。该研究遵循在PROSPERO（CRD42021259519）注册的方案。
结果
我们的分析确定了一系列生物标志物，突出了三种蛋白质——胱抑素B（CSTB）、磷酸丙糖异构酶（TPI1）和恶性脑肿瘤缺失1蛋白（DMBT1）——对胃癌诊断特别准确。
结论
唾液生物标志物在胃癌早期检测方面具有巨大潜力。未来的研究应致力于改进研究设计和验证，以提高这些生物标志物的质量和适用性。
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