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本文引用的文献

1
Atrial fibrillation and coronary artery disease: An integrative review focusing on therapeutic implications of this relationship.心房颤动与冠状动脉疾病：一项聚焦于这种关系治疗意义的综合综述。
World J Cardiol. 2023 May 26;15(5):229-243. doi: 10.4330/wjc.v15.i5.229.
2
Monomeric C-Reactive Protein in Atherosclerotic Cardiovascular Disease: Advances and Perspectives.单体 C 反应蛋白在动脉粥样硬化性心血管疾病中的作用：进展与展望。
Int J Mol Sci. 2023 Jan 20;24(3):2079. doi: 10.3390/ijms24032079.
3
Predictors of dementia amongst newly diagnosed non-valvular atrial fibrillation patients.新发非瓣膜性心房颤动患者痴呆的预测因素。
Indian Heart J. 2022 Nov-Dec;74(6):505-509. doi: 10.1016/j.ihj.2022.11.009. Epub 2022 Nov 30.
4
Put out the fire: The pleiotropic anti-inflammatory action of non-vitamin K oral anticoagulants.扑灭火灾：非维生素 K 口服抗凝剂的多效抗炎作用。
Pharmacol Res. 2022 Aug;182:106335. doi: 10.1016/j.phrs.2022.106335. Epub 2022 Jun 30.
5
Predictive role of C-reactive protein in sudden death: a meta-analysis of prospective studies.C 反应蛋白对心源性猝死预测作用的前瞻性研究荟萃分析
J Int Med Res. 2022 Feb;50(2):3000605221079547. doi: 10.1177/03000605221079547.
6
Atrial fibrillation burden and the risk of stroke: A systematic review and dose-response meta-analysis.心房颤动负荷与中风风险：一项系统评价和剂量反应荟萃分析。
World J Clin Cases. 2022 Jan 21;10(3):939-953. doi: 10.12998/wjcc.v10.i3.939.
7
Angiographic profile and outcomes in persistent non-valvular atrial fibrillation: A study from tertiary care center in North India.持续性非瓣膜性心房颤动的血管造影特征和结局：来自印度北部三级护理中心的研究。
Indian Heart J. 2022 Jan-Feb;74(1):7-12. doi: 10.1016/j.ihj.2021.12.010. Epub 2021 Dec 24.
8
Role of inflammation in atrial fibrillation: A comprehensive review of current knowledge.炎症在心房颤动中的作用：当前知识的全面综述。
J Arrhythm. 2020 Dec 23;37(1):1-10. doi: 10.1002/joa3.12473. eCollection 2021 Feb.
9
C-reactive protein for prediction of atrial fibrillation recurrence after catheter ablation.C 反应蛋白预测导管消融后心房颤动复发。
BMC Cardiovasc Disord. 2020 Sep 29;20(1):427. doi: 10.1186/s12872-020-01711-x.
10
2020 ESC Guidelines for the diagnosis and management of atrial fibrillation developed in collaboration with the European Association for Cardio-Thoracic Surgery (EACTS): The Task Force for the diagnosis and management of atrial fibrillation of the European Society of Cardiology (ESC) Developed with the special contribution of the European Heart Rhythm Association (EHRA) of the ESC.2020年欧洲心脏病学会（ESC）与欧洲心胸外科学会（EACTS）合作制定的心房颤动诊断和管理指南：欧洲心脏病学会（ESC）心房颤动诊断和管理特别工作组，由ESC欧洲心律协会（EHRA）特别贡献制定。
Eur Heart J. 2021 Feb 1;42(5):373-498. doi: 10.1093/eurheartj/ehaa612.

初始高敏 C 反应蛋白对非瓣膜性心房颤动结局的影响：一项观察性研究。

Impact of initial high sensitivity C-reactive protein on outcomes in nonvalvular atrial fibrillation: an observational study.

机构信息

Department of Cardiology, Dayanand Medical College and Hospital, Ludhiana, 141001, India.

Department of Internal Medicine, Post Graduate Institute of Medical Education & Research, Chandigarh, 160012, India.

出版信息

Future Cardiol. 2024 Apr 25;20(5-6):295-303. doi: 10.1080/14796678.2024.2354110. Epub 2024 Jun 10.

DOI:10.1080/14796678.2024.2354110
PMID:39120602
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11318744/
Abstract

The index study aimed to investigate the clinical impact of initial high-sensitivity C-reactive protein (hs-CRP) on outcomes in nonvalvular atrial fibrillation (AF). Single-center, prospective, observational study recruiting all recently diagnosed treatment-naive AF patients. Hs-CRP was measured at baseline and patients were followed for 24 months. A total of 126 patients with a mean age of 66.2 (±12.0) years were enrolled. The composite outcome of major adverse cardiac or cerebrovascular events (MACCE) occurred in 19 (17.7%) at 24 months. Raised initial hs-CRP emerged as an independent predictor of MACCE on regression analysis (OR: 1.569, 95% CI: 1.289-1.912;  < 0.001). Raised hs-CRP was an independent predictor of MACCE at 24 months. It allows for early identification of high-risk patients.

摘要

该指数研究旨在探讨初始高敏 C 反应蛋白（hs-CRP）对非瓣膜性心房颤动（AF）患者结局的临床影响。 这是一项单中心、前瞻性、观察性研究，招募了所有最近诊断的未经治疗的 AF 患者。在基线时测量 hs-CRP，患者随访 24 个月。共纳入 126 名平均年龄为 66.2（±12.0）岁的患者。24 个月时，19 名患者（17.7%）发生主要不良心脏或脑血管事件（MACCE）的复合结局。回归分析显示，初始 hs-CRP 升高是 MACCE 的独立预测因素（OR：1.569，95%CI：1.289-1.912；<0.001）。hs-CRP 升高是 24 个月时 MACCE 的独立预测因素。它可以早期识别高危患者。