Hasnain Muhammad Adeel, Kang Dae-Kyung, Moon Gi-Seong
Major in IT·Biohealth Convergence, Department of IT·Energy Convergence, Graduate School, Korea National University of Transportation, Chungju, 27469 Republic of Korea.
Department of Animal Resources Science, Dankook University, Cheonan, 31116 Republic of Korea.
Food Sci Biotechnol. 2024 Jun 24;33(9):2111-2121. doi: 10.1007/s10068-024-01626-9. eCollection 2024 Jul.
Gut represents one of the largest interfaces for the interaction of host factors and the environmental ones. Gut microbiota, largely dominated by bacterial community, plays a significant role in the health status of the host. The healthy gut microbiota fulfills several vital functions such as energy metabolism, disease protection, and immune modulation. Dysbiosis, characterized by microbial imbalance, can contribute to the development of various disorders, including intestinal, systemic, metabolic, and neurodegenerative conditions. Probiotics offer the potential to address dysbiosis and improve overall health. Advancements in high-throughput sequencing, bioinformatics, and omics have enabled mechanistic studies for the development of bespoke probiotics, referred to as next generation probiotics. These tailor-made probiotics have the potential to ameliorate specific disease conditions and thus fulfill the specific consumer needs. This review discusses recent updates on the most promising next generation probiotics, along with the challenges that must be addressed to translate this concept into reality.
肠道是宿主因素与环境因素相互作用的最大界面之一。肠道微生物群主要由细菌群落主导，在宿主的健康状况中发挥着重要作用。健康的肠道微生物群履行着多种重要功能，如能量代谢、疾病保护和免疫调节。以微生物失衡为特征的生态失调会导致各种疾病的发展，包括肠道、全身、代谢和神经退行性疾病。益生菌具有解决生态失调和改善整体健康的潜力。高通量测序、生物信息学和组学的进展使得针对定制益生菌（即下一代益生菌）的开发进行机制研究成为可能。这些量身定制的益生菌有潜力改善特定疾病状况，从而满足特定消费者的需求。本综述讨论了最有前景的下一代益生菌的最新进展，以及将这一概念转化为现实必须解决的挑战。
