Romero-Luna Haydee Eliza, Hernández-Mendoza Adrián, González-Córdova Aarón Fernando, Peredo-Lovillo Audry
Subdirección de Posgrado e Investigación, Instituto Tecnológico Superior de Xalapa, Xalapa 91096, Veracruz, Mexico.
Laboratorio de Química y Biotecnología de Productos Lácteos, Centro de Investigación en Alimentación y Desarrollo A.C. (CIAD, A.C.), Hermosillo 83304, Sonora, Mexico.
Food Chem X. 2021 Dec 22;13:100196. doi: 10.1016/j.fochx.2021.100196. eCollection 2022 Mar 30.
Synthetic biology is employed for the study and design of engineered microbes with new and improved therapeutic functions. The main advantage of synthetic biology is the selective genetic manipulation of living organisms with desirable beneficial effects such as probiotics. Engineering technologies have contributed to the edition of metabolic processes involved in the mechanisms of action of probiotics, such as the generation of bioactive peptides. Hence, current information related to bioactive peptides, produced by different engineering probiotics, with antimicrobial, antiviral, antidiabetic, and antihypertensive activities, as well as their potential use as functional ingredients, is discussed here. Besides, the effectiveness and safety aspects of these bioactive peptides were also described.
合成生物学被用于研究和设计具有新的和改进治疗功能的工程微生物。合成生物学的主要优势在于对生物体进行选择性基因操作以产生如益生菌等具有理想有益效果的物质。工程技术有助于对益生菌作用机制中涉及的代谢过程进行编辑，例如生物活性肽的产生。因此，本文讨论了由不同工程益生菌产生的、具有抗菌、抗病毒、抗糖尿病和抗高血压活性的生物活性肽的相关现有信息，以及它们作为功能成分的潜在用途。此外，还描述了这些生物活性肽的有效性和安全性方面。
