复方新诺明对血小板的免疫作用。
Immunological effect of co-trimoxazole on platelets.
作者信息
Claas F H, van der Meer J W, Langerak J
出版信息
Br Med J. 1979 Oct 13;2(6195):898-9. doi: 10.1136/bmj.2.6195.898.
Abstract
Diminished survival of transfused platelets occurred in two patients given co-trimoxazole, and a third patient taking this drug developed thrombocytopenia. By means of an indirect immunofluorescence assay antibodies against donor platelets coated with co-trimoxazole were found in the sera in all cases. These antibodies were directed against the trimethoprim component of co-trimoxazole and not against sulphamethoxazole. Co-trimoxazole is a potent antimicrobial agent and is advocated for treatment and prophylaxis in leukaemia. Hence its adverse effect on platelets is of great importance.
摘要
两名服用复方新诺明的患者出现了输注血小板存活率降低的情况，第三名服用该药物的患者发生了血小板减少症。通过间接免疫荧光试验，在所有病例的血清中均发现了针对被复方新诺明包被的供体血小板的抗体。这些抗体针对的是复方新诺明的甲氧苄啶成分，而非磺胺甲恶唑。复方新诺明是一种强效抗菌剂，被推荐用于白血病的治疗和预防。因此，其对血小板的不良反应具有重要意义。
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