Zhang Weihao, Li Yuming, Zheng Kai, Li Yuanjing, Yang Hua
Department of Neurosurgery, The Affiliated Hospital of Guizhou Medical University, Guizhou Medical University, Guizhou 610041, China.
Prev Med Rep. 2024 Jul 16;45:102830. doi: 10.1016/j.pmedr.2024.102830. eCollection 2024 Sep.
To explore the associations between dietary zinc intake and cardiovascular diseases (CVDs), including congestive heart failure (CHF), coronary heart disease (CHD), angina, heart attack, and cerebrovascular accident (CVA), this study was performed.
Data from the National Health and Nutrition Examination Survey (2005-2018) were used in this study. Dietary zinc intake was stratified into quartiles. Restricted cubic splines were constructed to assess nonlinear associations and identify cut-off values based on the type of nonlinearity. Binary logistic regressions were performed using the cut-offs.
Positive associations were detected between the second, third, and fourth quantiles of dietary zinc intake and decreased risks of overall CVDs (Q2: OR = 0.83, 95 % CI = 0.72-0.96; Q3: OR = 0.83, 95 % CI = 0.71-0.96; Q4: OR = 0.79, 95 % CI = 0.67-0.93). The second, third, and fourth quantiles were significantly associated with decreased risks of various CVDs (all < 0.05), except for CHD and angina (all > 0.05). Restricted cubic spline regression revealed significant nonlinear trends for associations of dietary zinc intake with the risk of developing CVDs and CHF (both for nonlinear <0.05), whereas those for heart attack and CVA were marginally significant ( for nonlinear = 0.072, and 0.075, respectively).
This study revealed that high dietary zinc intake is associated with reduced risks of developing CVDs, CHF, heart attack, and CVA, but not CHD or angina.
为探讨膳食锌摄入量与心血管疾病（CVD）之间的关联，包括充血性心力衰竭（CHF）、冠心病（CHD）、心绞痛、心脏病发作和脑血管意外（CVA），开展了本研究。
本研究使用了来自国家健康与营养检查调查（2005 - 2018年）的数据。膳食锌摄入量被分为四分位数。构建受限立方样条以评估非线性关联，并根据非线性类型确定临界值。使用这些临界值进行二元逻辑回归。
膳食锌摄入量的第二、第三和第四四分位数与总体心血管疾病风险降低之间存在正相关（Q2：OR = 0.83，95%CI = 0.72 - 0.96；Q3：OR = 0.83，95%CI = 0.71 - 0.96；Q4：OR = 0.79，95%CI = 0.67 - 0.93）。第二、第三和第四四分位数与各种心血管疾病风险降低显著相关（均<0.05），但冠心病和心绞痛除外（均>0.05）。受限立方样条回归显示，膳食锌摄入量与发生心血管疾病和充血性心力衰竭风险的关联存在显著非线性趋势（两者非线性P<0.05），而心脏病发作和脑血管意外的关联则具有边缘显著性（非线性P分别为0.072和0.075）。
本研究表明，高膳食锌摄入量与心血管疾病、充血性心力衰竭、心脏病发作和脑血管意外的发病风险降低有关，但与冠心病或心绞痛无关。
