• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

益生菌预防阴道感染：一项系统评价。

Probiotics for the Prevention of Vaginal Infections: A Systematic Review.

作者信息

Zuñiga Vinueza Andrea M

机构信息

School of Medicine, Universidad Catolica de Santiago de Guayaquil, Guayaquil, ECU.

出版信息

Cureus. 2024 Jul 13;16(7):e64473. doi: 10.7759/cureus.64473. eCollection 2024 Jul.

DOI:10.7759/cureus.64473
PMID:39135840
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11318795/
Abstract

Probiotics, particularly strains, have been proposed as an alternative or adjunct therapy for bacterial vaginosis (BV) and vulvovaginal candidiasis (VVC) due to their potential to restore a healthy vaginal microbiota. This systematic review evaluated 11 randomized controlled trials with a Jadad score greater than three, indicating high-quality studies based on criteria such as randomization, blinding, and dropout rates. The review demonstrated significant improvements in clinical outcomes and vaginal microbiota restoration. However, variability in results highlights the need for further research.

摘要

由于益生菌，特别是某些菌株，有恢复健康阴道微生物群的潜力，因此已被提议作为细菌性阴道病（BV）和外阴阴道念珠菌病（VVC）的替代或辅助治疗方法。本系统评价评估了11项Jadad评分大于3的随机对照试验，这表明这些研究基于随机化、盲法和失访率等标准属于高质量研究。该评价表明临床结局和阴道微生物群恢复有显著改善。然而，结果的变异性凸显了进一步研究的必要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a3a3/11318795/e671062db272/cureus-0016-00000064473-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a3a3/11318795/e671062db272/cureus-0016-00000064473-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a3a3/11318795/e671062db272/cureus-0016-00000064473-i01.jpg

相似文献

1
Probiotics for the Prevention of Vaginal Infections: A Systematic Review.益生菌预防阴道感染：一项系统评价。
Cureus. 2024 Jul 13;16(7):e64473. doi: 10.7759/cureus.64473. eCollection 2024 Jul.
2
Lactobacilli-containing vaginal probiotics to cure or prevent bacterial or fungal vaginal dysbiosis: a systematic review and recommendations for future trial designs.含乳杆菌的阴道益生菌治疗或预防细菌性或真菌性阴道菌群失调：系统评价及对未来试验设计的建议。
BJOG. 2020 Jan;127(2):287-299. doi: 10.1111/1471-0528.15870. Epub 2019 Aug 8.
3
Impact of -containing oral and vaginal probiotics on vaginal health: a randomised double-blind placebo controlled clinical trial.含[具体成分]的口服和阴道益生菌对阴道健康的影响：一项随机双盲安慰剂对照临床试验。 （你原文中“-containing”处应该有具体成分未给出完整，这里按格式补充翻译）
Benef Microbes. 2023 Apr 18;14(2):143-152. doi: 10.3920/BM2022.0091. Epub 2023 Mar 1.
4
Vaginal microbiota of asymptomatic bacterial vaginosis and vulvovaginal candidiasis: Are they different from normal microbiota?无症状细菌性阴道病和外阴阴道假丝酵母菌病的阴道微生物群：它们与正常微生物群有何不同？
Microb Pathog. 2019 Sep;134:103599. doi: 10.1016/j.micpath.2019.103599. Epub 2019 Jun 15.
5
Effectiveness of the association of 2 probiotic strains formulated in a slow release vaginal product, in women affected by vulvovaginal candidiasis: a pilot study.两种益生菌菌株联合阴道缓释产品治疗外阴阴道假丝酵母菌病的疗效：一项初步研究。
J Clin Gastroenterol. 2012 Oct;46 Suppl:S73-80. doi: 10.1097/MCG.0b013e3182684d71.
6
Interpretation of vaginal metagenomic characteristics in different types of vaginitis.不同类型阴道炎阴道微生物组特征的解读。
mSystems. 2024 Mar 19;9(3):e0137723. doi: 10.1128/msystems.01377-23. Epub 2024 Feb 16.
7
The role of diet and probiotics in prevention and treatment of bacterial vaginosis and vulvovaginal candidiasis in adolescent girls and non-pregnant women.饮食和益生菌在预防和治疗青少年女孩和非孕妇女性细菌性阴道病和外阴阴道念珠菌病中的作用。
Ginekol Pol. 2020;91(7):412-416. doi: 10.5603/GP.2020.0070.
8
Correlation Analysis of Vaginal Microbiome Changes and Bacterial Vaginosis Plus Vulvovaginal Candidiasis Mixed Vaginitis Prognosis.阴道微生态变化与细菌性阴道病合并外阴阴道假丝酵母菌病混合性阴道炎预后的相关性分析。
Front Cell Infect Microbiol. 2022 Mar 8;12:860589. doi: 10.3389/fcimb.2022.860589. eCollection 2022.
9
Treating vaginitis with probiotics in non-pregnant females: A systematic review and meta-analysis.非妊娠女性使用益生菌治疗阴道炎：一项系统评价与荟萃分析。
Exp Ther Med. 2020 Oct;20(4):3749-3765. doi: 10.3892/etm.2020.9090. Epub 2020 Aug 3.
10
Probiotics for vulvovaginal candidiasis in non-pregnant women.非孕妇外阴阴道念珠菌病的益生菌治疗
Cochrane Database Syst Rev. 2017 Nov 23;11(11):CD010496. doi: 10.1002/14651858.CD010496.pub2.

引用本文的文献

1
Nanoparticle-Driven Modulation of Mucosal Immunity and Interplay with the Microbiome.纳米颗粒驱动的黏膜免疫调节及其与微生物群的相互作用
J Microbiol Biotechnol. 2025 Jun 12;35:e2404033. doi: 10.4014/jmb.2504.04033.
2
Bacterial vaginosis.细菌性阴道病
Nat Rev Dis Primers. 2025 Jun 19;11(1):43. doi: 10.1038/s41572-025-00626-1.

本文引用的文献

1
Lacticaseibacillus rhamnosus TOM 22.8 (DSM 33500) is an effective strategy for managing vaginal dysbiosis, rising the lactobacilli population.鼠李糖乳杆菌 TOM 22.8（DSM 33500）是管理阴道菌群失调、提高乳杆菌数量的有效策略。
J Appl Microbiol. 2024 May 1;135(5). doi: 10.1093/jambio/lxae110.
2
Pregnancy outcomes in pregnant women taking oral probiotic undergoing cerclage compared to placebo: two blinded randomized controlled trial.口服益生菌行宫颈环扎术的孕妇与安慰剂相比的妊娠结局：两项双盲随机对照试验。
BMC Pregnancy Childbirth. 2024 May 9;24(1):311. doi: 10.1186/s12884-024-06496-x.
3
Lactobacillus probiotics restore vaginal and gut microbiota of pregnant women with vaginal candidiasis.
乳酸菌益生菌可恢复阴道念珠菌病孕妇的阴道和肠道微生物群。
Benef Microbes. 2023 Nov 23;14(5):421-431. doi: 10.1163/18762891-20220103.
4
VagiBIOM Lactobacillus suppository improves vaginal health index in perimenopausal women with bacterial vaginosis: a randomized control trial.VagiBIOM 乳杆菌阴道用胶囊改善细菌性阴道病围绝经期妇女的阴道健康指数：一项随机对照试验。
Sci Rep. 2024 Feb 9;14(1):3317. doi: 10.1038/s41598-024-53770-1.
5
Bacterial Vaginosis and Vulvovaginal Candidiasis Pathophysiologic Interrelationship.细菌性阴道病与外阴阴道假丝酵母菌病的病理生理相互关系。
Microorganisms. 2024 Jan 5;12(1):108. doi: 10.3390/microorganisms12010108.
6
Impact of -containing oral and vaginal probiotics on vaginal health: a randomised double-blind placebo controlled clinical trial.含[具体成分]的口服和阴道益生菌对阴道健康的影响：一项随机双盲安慰剂对照临床试验。 （你原文中“-containing”处应该有具体成分未给出完整，这里按格式补充翻译）
Benef Microbes. 2023 Apr 18;14(2):143-152. doi: 10.3920/BM2022.0091. Epub 2023 Mar 1.
7
Prevention of recurrence of bacterial vaginosis using lactobacilli-containing vaginal tablets among women with HIV: a randomized, placebo-controlled, double-blinded phase IV trial.在感染艾滋病毒的女性中使用含乳酸杆菌的阴道片预防细菌性阴道病复发：一项随机、安慰剂对照、双盲IV期试验。
Int J Infect Dis. 2023 Apr;129:197-204. doi: 10.1016/j.ijid.2023.02.003. Epub 2023 Feb 10.
8
Efficacy and Safety of MED-01 Probiotics on Vaginal Health: A 12-Week, Multicenter, Randomized, Double-Blind, Placebo-Controlled Clinical Trial.MED-01 益生菌对阴道健康的疗效和安全性：一项为期 12 周、多中心、随机、双盲、安慰剂对照的临床试验。
Nutrients. 2023 Jan 9;15(2):331. doi: 10.3390/nu15020331.
9
Probiotic treatment with specific lactobacilli does not improve an unfavorable vaginal microbiota prior to fertility treatment-A randomized, double-blinded, placebo-controlled trial.在接受生育治疗前，使用特定的乳酸杆菌进行益生菌治疗并不能改善不良的阴道微生物群-一项随机、双盲、安慰剂对照试验。
Front Endocrinol (Lausanne). 2022 Dec 1;13:1057022. doi: 10.3389/fendo.2022.1057022. eCollection 2022.
10
Sustained effect of LACTIN-V (Lactobacillus crispatus CTV-05) on genital immunology following standard bacterial vaginosis treatment: results from a randomised, placebo-controlled trial.标准细菌性阴道病治疗后阴道免疫持久效应：乳酸杆菌 crispatus CTV-05（LACTIN-V）的随机、安慰剂对照试验结果。
Lancet Microbe. 2022 Jun;3(6):e435-e442. doi: 10.1016/S2666-5247(22)00043-X. Epub 2022 Apr 21.