Yamazaki Yukiko, Matsuki Yuka, Hosokawa Koji, Tanaka Katsuya, Kawamura Yuko, Tanaka Aiko, Shigemi Kenji
Department of Intensive Care University of Fukui Hospital Fukui Japan.
Department of Anesthesiology and Reanimatology, Faculty of Medical Sciences University of Fukui Fukui Japan.
Health Sci Rep. 2024 Aug 12;7(8):e2315. doi: 10.1002/hsr2.2315. eCollection 2024 Aug.
Respiratory system compliance (Crs) is a simple indicator of lung flexibility. However, it remains unclear whether a low Crs during anesthesia induction (iCrs) is associated with an increased risk of postoperative mechanical ventilation.
This retrospective observational study was conducted using a local database. All mechanically ventilated postoperative ICU patients were included in this study. The duration of postoperative mechanical ventilation, length of hospital stay, and in-hospital mortality were compared between the low iCrs group (<25% of distribution) and the normal iCrs group.
A total of 315 patients were classified into the low iCrs (<39 mL/cmHO) group ( = 78) or the normal iCrs group ( = 237). Low iCrs was associated with a higher chance of mechanical ventilation in 28 days (log-rank test, < 0.001). The duration of hospital stay was similar. Multivariate analysis showed that in-hospital mortality was higher in the low iCrs group than in the normal iCrs group (adjusted odds ratio, 6.04 [1.13, 32.26]; = 0.04).
Low iCrs was associated with an increased risk of requiring postoperative mechanical ventilation. An additional result of poor survival related to low iCrs may require further study.
呼吸系统顺应性（Crs）是肺弹性的一个简单指标。然而，麻醉诱导期间低Crs（iCrs）是否与术后机械通气风险增加相关仍不清楚。
本回顾性观察性研究使用本地数据库进行。所有术后入住重症监护病房并接受机械通气的患者均纳入本研究。比较低iCrs组（分布的<25%）和正常iCrs组之间术后机械通气持续时间、住院时间和院内死亡率。
共315例患者被分为低iCrs（<39 mL/cmH₂O）组（n = 78）或正常iCrs组（n = 237）。低iCrs与28天内机械通气的更高几率相关（对数秩检验，P < 0.001）。住院时间相似。多因素分析显示，低iCrs组的院内死亡率高于正常iCrs组（调整后的优势比，6.04 [1.13, 32.26]；P = 0.04）。
低iCrs与术后需要机械通气的风险增加相关。低iCrs相关的生存不良这一额外结果可能需要进一步研究。
