Section of Rheumatology, Allergy and Immunology, Department of Internal Medicine, Yale School of Medicine, New Haven, Connecticut.
J Infect Dis. 2024 Aug 14;230(Supplement_1):S18-S26. doi: 10.1093/infdis/jiae250.
Lyme disease is a zoonotic infection due to Ixodes tick-transmitted Borrelia burgdorferi sensu lato spirochetes and the most common vector-borne disease in the Northern Hemisphere. Despite nearly 50 years of investigation, the pathogenesis of this infection and its 2 main adverse outcomes-postinfectious Lyme arthritis and posttreatment Lyme disease syndrome-are incompletely understood. Advancement in sequencing and mass spectrometry have led to the rapid expansion of high-throughput omics technologies, including transcriptomics, metabolomics, and proteomics, which are now being applied to human diseases. This review summarizes findings of omics studies conducted on blood and tissue samples of people with acute Lyme disease and its postinfectious outcomes.
莱姆病是一种由伊蚊传播的伯氏疏螺旋体引起的人畜共患病感染，是北半球最常见的虫媒传染病。尽管近 50 年来进行了大量研究，但这种感染的发病机制及其两种主要不良后果——感染后莱姆关节炎和治疗后莱姆病综合征仍不完全清楚。测序和质谱技术的进步导致高通量组学技术（包括转录组学、代谢组学和蛋白质组学）的快速扩展，现在这些技术正在被应用于人类疾病。本文综述了对急性莱姆病及其感染后结局患者的血液和组织样本进行的组学研究结果。
