Reed Zoe E, Thomas Richard, Boyd Andy, Griffith Gareth J, Morris Tim T, Rai Dheeraj, Manley David, Davey Smith George, Davis Oliver S P
MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.
School of Psychological Science, University of Bristol, Bristol, UK.
J Child Psychol Psychiatry. 2025 Feb;66(2):202-213. doi: 10.1111/jcpp.14047. Epub 2024 Aug 14.
The genetic and environmental aetiology of autistic and Attention Deficit Hyperactivity Disorder (ADHD) traits is known to vary spatially, but does this translate into variation in the association of specific common genetic variants?
We mapped associations between polygenic scores for autism and ADHD and their respective traits in the Avon Longitudinal Study of Parents and Children (N = 4,255-6,165) across the area surrounding Bristol, UK, and compared them to maps of environments associated with the prevalence of autism and ADHD.
Our results suggest genetic associations vary spatially, with consistent patterns for autistic traits across polygenic scores constructed at different p-value thresholds. Patterns for ADHD traits were more variable across thresholds. We found that the spatial distributions often correlated with known environmental influences.
These findings shed light on the factors that contribute to the complex interplay between the environment and genetic influences in autistic and ADHD traits.
已知自闭症和注意力缺陷多动障碍（ADHD）特征的遗传和环境病因在空间上存在差异，但这是否会转化为特定常见基因变异关联的差异呢？
我们在英国布里斯托尔周边地区的雅芳亲子纵向研究（样本量N = 4255 - 6165）中，绘制了自闭症和ADHD多基因得分与其各自特征之间的关联图谱，并将其与自闭症和ADHD患病率相关的环境图谱进行比较。
我们的结果表明基因关联在空间上存在差异，在不同p值阈值构建的多基因得分中，自闭症特征呈现出一致的模式。ADHD特征的模式在不同阈值下变化更大。我们发现空间分布通常与已知的环境影响相关。
这些发现揭示了在自闭症和ADHD特征中，促成环境与基因影响之间复杂相互作用的因素。
