School of Basic Medicine, Qingdao Medical College, Qingdao University, Qingdao 266003, China.
Food Funct. 2023 Aug 29;14(17):7780-7798. doi: 10.1039/d3fo02092d.
Gut inflammation seriously affects the healthy life of patients, and has a trend of increasing incidence rate. However, the current methods for treating gut inflammation are limited to surgery and drugs, which can cause irreversible damage to patients, especially infants. As natural oligosaccharides in human breast milk, human milk oligosaccharides (HMOs) function as probiotics in treating and preventing gut inflammation: improving the abundance of the gut microbiota, increasing the gut barrier function, and reducing the gut inflammatory reaction. Meanwhile, due to the complexity and high cost of their synthesis, people are searching for functional oligosaccharides that can replace HMOs as a food additive in infants milk powder and adjuvant therapy for chronic inflammation. The purpose of this review is to summarize the therapeutic and preventive effects of HMOs and their substitute functional oligosaccharides as probiotics in gut inflammation, and to summarize the prospect of their application in infant breast milk replacement in the future.
肠道炎症严重影响患者的健康生活，且发病率呈上升趋势。然而，目前治疗肠道炎症的方法仅限于手术和药物，这会对患者造成不可逆转的伤害，尤其是婴儿。人乳寡糖（HMOs）作为母乳中的天然低聚糖，在治疗和预防肠道炎症方面充当着益生菌的作用：改善肠道微生物群的丰度，增加肠道屏障功能，减少肠道炎症反应。同时，由于其合成的复杂性和高成本，人们正在寻找可替代 HMOs 的功能性寡糖，将其作为婴儿配方奶粉中的食品添加剂和慢性炎症的辅助治疗。本综述旨在总结 HMOs 及其替代功能性寡糖作为益生菌在肠道炎症中的治疗和预防作用，并总结其在未来替代婴儿母乳的应用前景。
