Cai Chen-Xi, Yu Shan-Shan, Xiong Xiao-Mei, Liu Bing-Qian, Lin Zhen-Qiang, Wang Qiang, Cui Jin-Li, Liu Ze-Hao, Li Tao, Lu Lin, Lin Ying
State Key Laboratory of Ophthalmology, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Clinic Department, Zhongshan Ophthalmic Center, Sun Yat-sen University, Tianhe District, No. 7, Jinsui Road, Guangzhou, 510060, China.
Capital Medical University Electric Teaching Hospital, State Grid Corporation of China Beijing Electric Power Hospital, Beijing, 100073, China.
Geroscience. 2024 Aug 15. doi: 10.1007/s11357-024-01298-7.
To determine age-related alterations in vortex veins in healthy subjects. A total of 228 healthy subjects (aged 4 to 86 years) were recruited and divided into four groups (G1, <21 years; G2, 21-40 years; G3, 41-60 years; and G4, 61-86 years). The clinical characteristics of the participants were recorded, and parameters including the number of vortex vein roots (NVVR), the central vortex vein diameter (CVVD), the mean root area of the vortex vein (MRAVV), and the weighted mean of the thickest branch diameter (WMTBD) were obtained by marking the vortex veins on indocyanine green angiography (ICGA). The NVVR in the age group over 60 years old was significantly lower than that in other age groups (P < 0.05). The CVVD, MRAVV, and WMTBD of all age groups increased with increasing age (P < 0.05). The NVVR was unevenly distributed among the quadrants (P < 0.001). The proportions of type four vortex veins (complete systems including ampulla) and anastomotic branches of the vortex veins were significantly increased in elderly participants over 50 years of age (P < 0.05). Subfoveal choroidal thickness was significantly correlated with age, NVVR, CVVD and MRAVV (P < 0.05). This is the first study to reveal age-related alterations in vortex veins on ICGA in a healthy population. Aging may lead to partial vortex occlusion and residual vortex dilation. As age increases, anastomotic branches increasingly appear between the originally independent vortex veins. Translational relevance: Aging may lead to partial vortex occlusion and residual vortex dilation.
确定健康受试者涡静脉的年龄相关变化。共招募了228名健康受试者（年龄4至86岁），并将其分为四组（G1，<21岁；G2，21 - 40岁；G3，41 - 60岁；G4，61 - 86岁）。记录参与者的临床特征，并通过在吲哚菁绿血管造影（ICGA）上标记涡静脉获得包括涡静脉根部数量（NVVR）、中央涡静脉直径（CVVD）、涡静脉平均根部面积（MRAVV）以及最粗分支直径的加权平均值（WMTBD）等参数。60岁以上年龄组的NVVR显著低于其他年龄组（P < 0.05）。所有年龄组的CVVD、MRAVV和WMTBD均随年龄增长而增加（P < 0.05）。NVVR在各象限分布不均（P < 0.001）。50岁以上老年参与者中四型涡静脉（包括壶腹的完整系统）和涡静脉吻合支的比例显著增加（P < 0.05）。黄斑下脉络膜厚度与年龄、NVVR、CVVD和MRAVV显著相关（P < 0.05）。这是第一项揭示健康人群ICGA上涡静脉年龄相关变化的研究。衰老可能导致部分涡静脉闭塞和残余涡静脉扩张。随着年龄增长，原本独立的涡静脉之间越来越多地出现吻合支。转化相关性：衰老可能导致部分涡静脉闭塞和残余涡静脉扩张。
