正常受试者、维持性血液透析的终末期肾衰竭患者及肾移植后患者的血浆25-羟维生素D水平

Plasma 25-hydroxy-vitamin D in normal subjects and patients with terminal renal failure, on maintenance haemodialysis and after transplantation.

Eastwood J B, Daly A, Carter G D, Alaghband-Zadeh J, De Wardener H E

Clin Sci (Lond). 1979 Nov;57(5):473-6. doi: 10.1042/cs0570473.

Abstract

Plasma 25-hydroxy-vitamin D concentration was measured in 40 normal subjects, 19 patients with terminal renal failure, 137 patients who had been on dialysis up to 11 years and in 17 renal transplant patients. 2. The mean plasma concentration of 25-hydroxy-vitamin D was below normal in patients with terminal renal failure and in patients who had been on maintenance haemodialysis for less than 1 year. The mean concentration in patients who had been on dialysis for more than 1 year and in renal transplant patients was normal. 3. The seasonal variation of plasma 25-hydroxy-vitamin D concentration found in the 58 patients on maintenance haemodialysis for more than 2 years is similar to that reported in normal subjects.

摘要

对40名正常受试者、19名终末期肾衰竭患者、137名接受透析长达11年的患者以及17名肾移植患者测量了血浆25-羟基维生素D浓度。2. 终末期肾衰竭患者和维持性血液透析不足1年的患者血浆25-羟基维生素D的平均浓度低于正常水平。透析超过1年的患者和肾移植患者的平均浓度正常。3. 在58名接受维持性血液透析超过2年的患者中发现的血浆25-羟基维生素D浓度的季节性变化与正常受试者中报道的相似。