Department of Molecular Biology of Cancer, Institute of Experimental Medicine, The Czech Academy of Sciences, Videnska 1083, Prague 142 20, Czech Republic; Institute of Biology and Medical Genetics, First Faculty of Medicine, Charles University, Prague 128 00, Czech Republic; Faculty of Medicine and Biomedical Center in Pilsen, Charles University, Pilsen 306 05, Czech Republic.
Biomedical Center Martin, Central Laboratories and Scientific Research Groups, Comenius University in Bratislava, Jessenius Faculty of Medicine, Martin 036 01, Slovakia.
Mutat Res Genet Toxicol Environ Mutagen. 2024 Aug-Sep;898:503806. doi: 10.1016/j.mrgentox.2024.503806. Epub 2024 Jul 25.
Stainless steel welders are exposed to heavy filler metals. We evaluated the concentration of these metals in whole blood and urine, and the relevant biochemical parameters in relation to the total chromosomal aberrations (CAs), chromatid-type (CTA-type, CTAs) and chromosome-type (CSA-type, CSAs), in 117 welders and control individuals. Statistically higher concentrations of the total Cr, Ni and Mn were observed in whole blood and urine of welders, and the concentrations were higher in welders who smoked. On the contrary, concentrations of urinary heavy metals Cr and Mn adjusted for creatinine were significantly higher in the control groups. A statistically higher frequency of total CAs was observed in the whole group of welders, and also in the non-smoking welders, as compared to controls. The frequency of total CAs significantly correlated with the concentration of Cr, Ni and Mn in whole blood (R=0.61, P˂0.0001, R=0.33, P˂0.0001 and R=0.66, P˂0.0001, respectively), with urinary concentrations of Ni and Mn (R=0.27, P=0.003 and R=0.28, P=0.003, respectively) and with urinary concentrations of Cr, Ni and Mn adjusted for creatinine (R=0.22, P=0.029, R=0.26, P=0.005 and R=0.20, P=0.030, respectively). Likewise, the frequency of CTA-types significantly correlated with the concentration of Cr and Mn in whole blood (R=0.31, P=0.0007 and R=0.34, P=0.0002). The frequency of CSA-types significantly correlated with concentrations of Cr, Ni and Mn in whole blood (R=0.43, P˂0.0001, R=0.38, P˂0.0001 and R=0.46, P˂0.0001, respectively). The statistically higher values of serum creatinine and total bilirubin were detected in all welders, as well as in smokers when compared to the corresponding controls. The exposure to heavy metals in welders increased the frequencies of CAs and altered the balance between urinary excretion of heavy metals and their possible accumulation.
不锈钢焊工接触大量填充金属。我们评估了这些金属在全血和尿液中的浓度，以及与总染色体畸变（CAs）、染色单体型（CTA 型，CTAs）和染色体型（CSA 型，CSAs）相关的相关生化参数，共评估了 117 名焊工和对照组个体。我们发现，与对照组相比，全血和尿液中的总铬、镍和锰浓度在焊工中明显更高，而且吸烟的焊工中这些金属浓度更高。相反，调整肌酐后的尿液重金属铬和锰浓度在对照组中明显更高。与对照组相比，整个焊工组以及非吸烟焊工的总 CAs 频率明显更高。总 CAs 频率与全血中 Cr、Ni 和 Mn 的浓度显著相关（R=0.61，P＜0.0001，R=0.33，P＜0.0001 和 R=0.66，P＜0.0001），与尿中 Ni 和 Mn 的浓度相关（R=0.27，P=0.003 和 R=0.28，P=0.003），与调整肌酐后的尿中 Cr、Ni 和 Mn 浓度相关（R=0.22，P=0.029，R=0.26，P=0.005 和 R=0.20，P=0.030）。同样，CTA 型的频率与全血中 Cr 和 Mn 的浓度显著相关（R=0.31，P=0.0007 和 R=0.34，P=0.0002）。CSA 型的频率与全血中 Cr、Ni 和 Mn 的浓度显著相关（R=0.43，P＜0.0001，R=0.38，P＜0.0001 和 R=0.46，P＜0.0001）。与相应的对照组相比，所有焊工以及吸烟者的血清肌酐和总胆红素值均升高。焊工接触重金属会增加 CAs 的频率，并改变重金属在尿液中的排泄与可能积累之间的平衡。
