Department of Environmental and Biological Monitoring, Nofer Institute of Occupational Medicine, Lodz, Poland.
Department of Biostatistics and Translational Medicine, Medical University of Lodz, Poland.
Toxicol Lett. 2020 Sep 1;329:47-55. doi: 10.1016/j.toxlet.2020.04.019. Epub 2020 May 5.
The aim of the study was to determine the concentration of hexavalent and trivalent chromium, nickel, manganese, and iron in welding fumes (WFs) and to evaluate the significant association between the concentration of metals in the biological material of welders. The studies were conducted in welders (n = 67) and controls (n = 52). Stainless steel WFs were continuously collected in the workers' breathing zone during a shift. The serum and urine concentrations of Cr and Ni were determined by ICP-MS. The content of Mn in the whole blood was determined using ET-AAS. The content of Cr in the erythrocytes was determined using ICP-MS. The Cr concentration in the welders' urine positively correlated with a work environment concentration of Cr (R = 0.59, p < 0.0001), Cr(VI) (R = 0.58, p < 0.0001), and Cr(III) (R = 0.64, p < 0.0001) in the inhalable fraction. The Ni concentration in the welders' urine positively correlated with the Ni concentration in the inhalable and respirable fraction (R = 0.34, p < 0.005 and R = 0.44, p < 0.002). The correlation between the Mn concentration in the work environment air and the Mn concentration in the welders' whole blood (R = 0.46, p < 0.0001) was observed.
本研究旨在测定焊接烟尘（Welding Fumes，WFs）中六价铬、三价铬、镍、锰和铁的浓度，并评估焊工生物材料中金属浓度之间的显著相关性。研究对象为 67 名焊工和 52 名对照者。在轮班过程中，连续在工人呼吸区采集不锈钢 WFs。采用 ICP-MS 法测定血清和尿中 Cr 和 Ni 浓度，采用 ET-AAS 法测定全血中 Mn 含量，采用 ICP-MS 法测定红细胞中 Cr 含量。焊工尿 Cr 浓度与工作环境中 Cr（R=0.59，p<0.0001）、Cr(VI)（R=0.58，p<0.0001）和 Cr(III)（R=0.64，p<0.0001）浓度呈正相关。焊工尿中 Ni 浓度与可吸入和可呼吸部分的 Ni 浓度呈正相关（R=0.34，p<0.005 和 R=0.44，p<0.002）。工作环境空气中 Mn 浓度与焊工全血中 Mn 浓度呈正相关（R=0.46，p<0.0001）。
