School of Exercise and Health, Shanghai University of Sport, Shanghai, China.
Physical Education College, Henan Sport University, Zhengzhou, China.
Front Endocrinol (Lausanne). 2024 Aug 1;15:1401342. doi: 10.3389/fendo.2024.1401342. eCollection 2024.
Type 2 diabetes (T2D) is a common chronic metabolic disease, and its prevalence is increasing globally. Exercise is crucial for T2D management, yet many aspects of its mechanisms remain unclear. This study employs CiteSpace to reveal research hotspots and frontier issues in exercise intervention for T2D.
A literature review spanning from January 1, 2013 to December 31, 2022, was conducted using the Web of Science Core Collection (WoSCC), with keywords including "exercise," "type 2 diabetes," and "mechanisms." We analyzed network diagrams generated by CiteSpace, which depicted relationships among countries, authors, and keywords.
This study includes 1,210 English papers from 555 journals, affiliated with 348 institutions across 80 countries/regions. Notably, the United States, China, and the United Kingdom account for nearly half of all publications. The University of Copenhagen leads in publication volume, followed by Harvard Medical School and the University of Colorado. Key authors include Kirwan, John P (Case Western Reserve University), Malin, Steven K (Rutgers University), and Pedersen, Bente Klarlund (University of Copenhagen). Based on co-occurrence analysis of keywords, it is evident that terms such as "disease," "glucagon-like peptide 1," and "cardiovascular risk factor" exhibit high intermediary centrality.
The analysis highlights ongoing investigations into molecular mechanisms, such as β-cell function enhancement, exerkines, and epigenetic mechanisms. Emerging areas include exercise response heterogeneity, circadian rhythm regulation, transcription factors, neurotrophic factors, and mitochondrial function. Future studies should prioritize understanding interactions between different exercise mechanisms and optimizing exercise prescriptions for T2D. Exercise prescriptions are crucial for effective interventions. Collaboration between countries and institutions is essential to understand the influences of different genetic backgrounds and environmental factors. Currently, a combination of aerobic and resistance training is considered the optimal form of exercise. However, considering time efficiency, high-intensity interval training (HIIT) has gained widespread attention and research due to its ability to achieve similar exercise effects in a shorter duration. Additionally, circadian rhythm regulation may affect the exercise outcomes of diabetic individuals at different times of the day, particularly concerning the specific types, doses, and intensities used for precision intervention in T2D.
2 型糖尿病（T2D）是一种常见的慢性代谢性疾病，其全球患病率正在不断上升。运动对于 T2D 的管理至关重要，但运动干预的许多机制仍不清楚。本研究采用 CiteSpace 揭示 T2D 运动干预的研究热点和前沿问题。
使用 Web of Science 核心合集（WoSCC）对 2013 年 1 月 1 日至 2022 年 12 月 31 日的文献进行综述，检索词包括“运动”、“2 型糖尿病”和“机制”。我们分析了 CiteSpace 生成的网络图，该图描绘了国家、作者和关键词之间的关系。
本研究共纳入 1210 篇来自 555 种期刊的英文论文，涉及 80 个国家/地区的 348 个机构。值得注意的是，美国、中国和英国的出版物几乎占总数的一半。哥本哈根大学在发表量方面处于领先地位，其次是凯斯西储大学和科罗拉多大学。关键作者包括 Kirwan，John P（凯斯西储大学）、Malin，Steven K（罗格斯大学）和 Pedersen，Bente Klarlund（哥本哈根大学）。基于关键词共现分析，很明显，“疾病”、“胰高血糖素样肽 1”和“心血管风险因素”等术语具有较高的中介中心性。
该分析突出了对分子机制的持续研究，例如β细胞功能增强、外泌体和表观遗传机制。新兴领域包括运动反应异质性、昼夜节律调节、转录因子、神经营养因子和线粒体功能。未来的研究应优先理解不同运动机制之间的相互作用，并优化 T2D 的运动处方。运动处方对于有效的干预至关重要。国家和机构之间的合作对于理解不同遗传背景和环境因素的影响至关重要。目前，有氧运动和抗阻运动的结合被认为是最佳的运动形式。然而，考虑到时间效率，高强度间歇训练（HIIT）由于能够在更短的时间内达到类似的运动效果而受到广泛关注和研究。此外，昼夜节律调节可能会影响糖尿病患者在一天中不同时间的运动结果，特别是在 T2D 的精确干预中，涉及特定类型、剂量和强度的应用。
