Harris Benjamin A, Zhou Jinpeng, Clarke Bradley O, Leung Ivanhoe K H
School of Chemistry and Bio21 Molecular Science & Biotechnology Institute, The University of Melbourne, Parkville, VIC, 3010, Australia.
Australian Laboratory for Emerging Contaminants, School of Chemistry, The University of Melbourne, Parkville, VIC, 3010, Australia.
ChemSusChem. 2025 Jan 14;18(2):e202401122. doi: 10.1002/cssc.202401122. Epub 2024 Oct 23.
Per- and polyfluoroalkyl substances (PFAS) are often considered the quintessential example of industrial chemical pollution - they are toxic and ubiquitous environmental contaminants that are extremely difficult to degrade. There has been a large research focus on the development of effective and renewable degradation technologies. In comparison to traditional pollutant degradation techniques, such as advanced oxidation processes and electrochemistry, degradation of PFAS using extracellular enzymes offers an eco-friendly solution as enzymes are biodegradable, recyclable and have low energy and chemical requirements. This review outlines the current understanding of extracellular enzymatic degradation of PFAS with a focus on reported results and proposed degradation mechanisms. More importantly, this review highlights limitations that hinder the application of enzymes for PFAS degradation and proposes critical future research that is needed to improve the applicability of this promising remediation strategy.
全氟和多氟烷基物质（PFAS）通常被视为工业化学污染的典型例子——它们是有毒且无处不在的环境污染物，极难降解。目前已有大量研究聚焦于开发有效且可再生的降解技术。与传统污染物降解技术（如高级氧化工艺和电化学）相比，利用细胞外酶降解PFAS提供了一种生态友好的解决方案，因为酶具有生物可降解性、可回收性，且对能量和化学物质的需求较低。本综述概述了目前对PFAS细胞外酶降解的理解，重点关注已报道的结果和提出的降解机制。更重要的是，本综述强调了阻碍酶用于PFAS降解的局限性，并提出了未来关键的研究方向，以提高这种有前景的修复策略的适用性。
