Kranyak Allison, Haran Kathryn, Smith Payton, Johnson Chandler, Liao Wilson, Bhutani Tina
Department of Dermatology, University of California San Francisco, San Francisco, CA, USA.
Institute for Human Genetics, University of California San Francisco, San Francisco, CA, USA.
J Psoriasis Psoriatic Arthritis. 2024 Apr;9(2):69-81. doi: 10.1177/24755303241226626. Epub 2024 Jan 9.
Adherence to a Mediterranean Diet (MeD) has been associated with lower disease severity in patients with psoriasis. However, the mechanism behind how this diet may lead to disease modification remain understudied. Recent studies have revealed dysbiosis of the gut microbiome in patients with psoriasis suggestive of inflammation and altered immune regulation. Diet affects the gut microbiome and this review aims to evaluate whether correcting this dysbiosis may be one theoretical mechanism by which the MeD may be associated with lower psoriasis severity.
A literature search of the PubMed database was conducted for the terms 1) 'psoriasis' and 'microbiome' or 'microbiota,' and 2) 'Mediterranean diet' and 'microbiome' or 'microbiota' with manual screening for relevant articles. In total, we identified 9 relevant primary research studies investigating the gut microbiome in patients with psoriasis and 16 relevant primary research studies investigating changes in the microbiota for those consuming a MeD.
Though varying in exact levels of certain bacteria, studies analyzing the microbiome in psoriasis revealed dysbiosis. Those analyzing the effect of the Mediterranean diet on the microbiome revealed beneficial changes, including alleviating some of the same alterations seen in the microbiome of those with psoriasis.
Microbiota change is a possible mechanism why the MeD has previously been associated with lower psoriasis severity.
坚持地中海饮食（MeD）与银屑病患者较低的疾病严重程度相关。然而，这种饮食方式导致疾病改善的背后机制仍未得到充分研究。最近的研究表明，银屑病患者的肠道微生物群失调，提示存在炎症和免疫调节改变。饮食会影响肠道微生物群，本综述旨在评估纠正这种失调是否可能是地中海饮食与较低银屑病严重程度相关的一种理论机制。
在PubMed数据库中进行文献检索，检索词为1）“银屑病”和“微生物组”或“微生物群”，以及2）“地中海饮食”和“微生物组”或“微生物群”，并手动筛选相关文章。我们总共确定了9项关于银屑病患者肠道微生物群的相关初步研究，以及16项关于食用地中海饮食者微生物群变化的相关初步研究。
尽管某些细菌的确切水平有所不同，但分析银屑病微生物组的研究显示存在失调。那些分析地中海饮食对微生物组影响的研究显示出有益的变化，包括缓解了银屑病患者微生物组中出现的一些相同改变。
微生物群变化可能是地中海饮食此前与较低银屑病严重程度相关的一个机制。
