Armet Anissa M, Deehan Edward C, O'Sullivan Aidan F, Mota João F, Field Catherine J, Prado Carla M, Lucey Alice J, Walter Jens
Department of Agricultural, Food & Nutritional Science, University of Alberta, Edmonton, AB T6G 2E1, Canada.
Cork Centre for Vitamin D and Nutrition Research, School of Food & Nutritional Sciences, University College Cork, Cork T12 HY8E, Ireland; APC Microbiome Ireland, School of Microbiology, and Department of Medicine, University College Cork, Cork T12 YT20, Ireland.
Cell Host Microbe. 2022 Jun 8;30(6):764-785. doi: 10.1016/j.chom.2022.04.016.
Given the worldwide epidemic of diet-related chronic diseases, evidence-based dietary recommendations are fundamentally important for health promotion. Despite the importance of the human gut microbiota for the physiological effects of diet and chronic disease etiology, national dietary guidelines around the world are just beginning to capitalize on scientific breakthroughs in the microbiome field. In this review, we discuss contemporary nutritional recommendations from a microbiome science perspective, focusing on mechanistic evidence that established host-microbe interactions as mediators of the physiological effects of diet. We apply this knowledge to inform discussions of nutrition controversies, advance innovative dietary strategies, and propose an experimental framework that integrates the microbiome into nutrition research. The congruence of key paradigms in the nutrition and microbiome disciplines validates current recommendations in dietary guidelines, and the systematic incorporation of microbiome science into nutrition research has the potential to further improve and innovate healthy eating.
鉴于与饮食相关的慢性病在全球流行，基于证据的饮食建议对促进健康至关重要。尽管人类肠道微生物群对饮食的生理效应和慢性病病因学具有重要意义，但世界各地的国家饮食指南才刚刚开始利用微生物组领域的科学突破。在本综述中，我们从微生物组科学的角度讨论当代营养建议，重点关注将宿主-微生物相互作用确立为饮食生理效应介导因素的机制证据。我们运用这些知识为营养争议的讨论提供信息，推进创新的饮食策略，并提出一个将微生物组纳入营养研究的实验框架。营养和微生物组学科中关键范式的一致性验证了饮食指南中的当前建议，将微生物组科学系统地纳入营养研究有可能进一步改进和创新健康饮食。
