Patil Rajvardhan, Kumar Sunil, Acharya Sourya, Karwa Vineet, Shaikh Suhail M, Kothari Manjeet
Internal Medicine, Jawaharlal Nehru Medical College, Datta Meghe Institute of Higher Education and Research, Wardha, IND.
Medicine, Jawaharlal Nehru Medical College, Datta Meghe Institute of Higher Education and Research, Wardha, IND.
Cureus. 2024 Jul 19;16(7):e64901. doi: 10.7759/cureus.64901. eCollection 2024 Jul.
Epileptic encephalopathy (EE) represents a challenging group of disorders characterized by severe epilepsy and significant cognitive, behavioral, and neurological impairments. This comprehensive review aims to elucidate the current insights into the pathogenesis and therapeutic strategies for these disorders. Pathogenesis involves a complex interplay of genetic factors, neurobiological mechanisms, and environmental influences that contribute to the severity and progression of symptoms. Clinical manifestations are diverse, encompassing various seizure types, cognitive and behavioral impairments, and developmental delays. Current therapeutic strategies include pharmacological treatments, nonpharmacological interventions, and emerging therapies such as gene and stem cell therapy. Despite advancements, significant challenges and limitations remain, highlighting the need for ongoing research and innovation. This review synthesizes existing knowledge, identifies research gaps, and proposes future directions, emphasizing the potential for personalized medicine to improve patient outcomes and quality of life.
癫痫性脑病（EE）是一组具有挑战性的疾病，其特征为严重癫痫以及显著的认知、行为和神经功能障碍。这篇综述旨在阐明目前对这些疾病发病机制和治疗策略的认识。发病机制涉及遗传因素、神经生物学机制和环境影响之间的复杂相互作用，这些因素导致了症状的严重程度和进展。临床表现多种多样，包括各种发作类型、认知和行为障碍以及发育迟缓。目前的治疗策略包括药物治疗、非药物干预以及基因和干细胞治疗等新兴疗法。尽管取得了进展，但仍存在重大挑战和局限性，这凸显了持续研究和创新的必要性。本综述综合了现有知识，确定了研究差距，并提出了未来方向，强调了个性化医疗改善患者预后和生活质量的潜力。
