Kou Haiyang, Qing Zhong, Guo Hao, Zhang Rui, Ma Jianbing
The First Clinical Medical College, Shaanxi University of Chinese Medicine, Xianyang, 712046, Shaanxi, China.
Translational Medicine Center, Honghui Hospital, Xi'an Jiaotong University, Xi'an, 710000, Shaanxi, China.
Eur J Clin Nutr. 2023 Feb;77(2):166-172. doi: 10.1038/s41430-022-01148-9. Epub 2022 Apr 25.
The purpose of this study was to evaluate the safety and effectiveness of vitamin E in rheumatoid arthritis patients.
A computerized search of PubMed, Embase, The Cochrane Library, and Web of Science databases was conducted to find published randomized controlled trials of vitamin E in rheumatoid arthritis; the experimental group was treated with vitamin E, while the control group was treated with placebo, other drugs, or external therapy; the search period was from the time each database was established to December 31, 2021, and a meta-analysis was conducted using Rev Man 5.4 software.
This research eventually comprised nine publications with a total of 39,845 patients. Vitamin E supplementation was shown to be more effective in individuals with RA for sensitive joints (MD = -1.66, 95% CI - -6.32-2.99; I = 93%; P < 0.00001) and swollen joints (MD = -0.46, 95% CI - -1.98-1.07; I = 56%; P = 0.08).
Vitamin E's ability to restore the intestinal barrier and improve the gastrointestinal tract may be linked to the prevention and treatment of rheumatoid arthritis. Vitamin E supplements used on a regular basis can help individuals with RA reduce joint discomfort, edema, and stiffness, as well as enhance their overall quality of life.
本研究旨在评估维生素E在类风湿关节炎患者中的安全性和有效性。
对PubMed、Embase、Cochrane图书馆和Web of Science数据库进行计算机检索，以查找已发表的关于维生素E治疗类风湿关节炎的随机对照试验；试验组接受维生素E治疗，对照组接受安慰剂、其他药物或外部治疗；检索期从各数据库建立时间至2021年12月31日，并使用Rev Man 5.4软件进行荟萃分析。
本研究最终纳入9篇文献，共39845例患者。补充维生素E对类风湿关节炎患者的敏感关节（MD = -1.66，95%CI - -6.32至2.99；I = 93%；P < 0.00001）和肿胀关节（MD = -0.46，95%CI - -1.98至1.07；I = 56%；P = 0.08）显示出更有效的效果。
维生素E恢复肠道屏障和改善胃肠道的能力可能与类风湿关节炎的防治有关。定期使用维生素E补充剂可帮助类风湿关节炎患者减轻关节不适、水肿和僵硬，提高其整体生活质量。
