Gaffin S L, Wells M, Jordan J P
Br J Radiol. 1985 Sep;58(693):881-4. doi: 10.1259/0007-1285-58-693-881.
Death in humans from ionising radiation overexposure in the 3-8 Gy (300-800 rad) range is in part due to the toxaemia caused by the entry of gram-negative bacteria and/or their lipopolysaccharide toxin (LPS) into the blood circulation through the walls of partially denuded gut. Anti-LPS hyperimmune equine plasma was evaluated for its ability to lower irradiation-induced lethality. Mice were irradiated with 6.3 Gy (630 rad) and six days later received equine Anti-LPS hyperimmune plasma, control plasma or saline. Mortalities in the three groups were 58%, 92% and 79% (p less than 0.01) respectively. Thus Anti-LPS may prove useful as an adjunct to conventional therapy in treating radiation sickness.
人类在3 - 8戈瑞（300 - 800拉德）范围内因电离辐射过度暴露而死亡，部分原因是革兰氏阴性菌及其脂多糖毒素（LPS）通过部分剥脱的肠壁进入血液循环所引起的毒血症。对马抗LPS超免疫血浆降低辐射诱导致死率的能力进行了评估。小鼠接受6.3戈瑞（630拉德）的照射，六天后分别接受马抗LPS超免疫血浆、对照血浆或生理盐水。三组的死亡率分别为58%、92%和79%（p小于0.01）。因此，抗LPS可能被证明是治疗放射病的传统疗法的有用辅助手段。
