Division of Nephrology, Nanfang Hospital, Southern Medical University, National Clinical Research Center for Kidney Disease, State Key Laboratory of Organ Failure Research, Guangdong Provincial Institute of Nephrology, Guangdong Provincial Key Laboratory of Renal Failure Research, Guangzhou Regenerative Medicine and Health Guangdong Laboratory, Guangzhou, China.
Diabetes Obes Metab. 2024 Nov;26(11):5147-5156. doi: 10.1111/dom.15859. Epub 2024 Aug 19.
To assess the association of intake of sugar-sweetened beverages (SSBs), artificially sweetened beverages (ASBs) and natural juices (NJs) with new-onset atrial fibrillation (AF) in people with prediabetes or diabetes.
A total of 31 433 participants with prediabetes and diabetes from the UK Biobank were included. Information on the intake of SSBs, ASBs and NJs was accessed by 24-hour dietary recalls from 2009 to 2012. The study outcome was new-onset AF.
During a median follow-up of 12.0 years, 2470 (7.9%) AF cases were documented. Both the intake of SSBs (per 1 unit/day increment; adjusted hazard ratio [HR] = 1.11; 95% confidence interval [CI]: 1.04-1.18) and ASBs (per 1 unit/day increment; adjusted HR = 1.08; 95% CI: 1.02-1.14) were linearly and positively associated with new-onset AF, while NJ intake was not significantly associated with new-onset AF (per 1 unit/day increment; adjusted HR = 1.00; 95% CI: 0.93-1.08). Accordingly, compared with non-consumers, participants who consumed more than one unit per day of SSBs (adjusted HR = 1.30; 95% CI: 1.11-1.53) or ASBs (adjusted HR = 1.21; 95% CI:1.05-1.40) had an increased risk of AF. Substituting 1 unit/day of NJs for SSBs was associated with a 9% (adjusted HR = 0.91; 95% CI: 0.83-0.99) lower risk of new-onset AF, while replacing SSBs with ASBs was not significantly associated with new-onset AF (adjusted HR = 0.97; 95% CI: 0.89-1.06).
Both the intake of SSBs and ASBs were linearly and positively associated with new-onset AF, while NJ intake did not show a significant association with AF in people with prediabetes or diabetes. Replacing an equivalent amount of SSB intake with NJs, but not ASBs, was associated with a lower risk of AF.
评估摄入含糖饮料（SSB）、人工甜味饮料（ASB）和天然果汁（NJ）与糖尿病前期或糖尿病患者新发心房颤动（AF）的相关性。
共纳入英国生物银行 31433 例糖尿病前期和糖尿病患者。通过 2009 年至 2012 年的 24 小时膳食回忆，获取 SSB、ASB 和 NJ 摄入的信息。研究结果为新发 AF。
在中位随访 12.0 年期间，记录了 2470 例（7.9%）AF 病例。SSB（每增加 1 个单位/天；调整后的危险比 [HR] = 1.11；95%置信区间 [CI]：1.04-1.18）和 ASB（每增加 1 个单位/天；调整后的 HR = 1.08；95% CI：1.02-1.14）的摄入量均与新发 AF 呈线性正相关，而 NJ 摄入量与新发 AF 无显著相关性（每增加 1 个单位/天；调整后的 HR = 1.00；95% CI：0.93-1.08）。因此，与非消费者相比，每天摄入超过 1 个单位 SSB（调整后的 HR = 1.30；95% CI：1.11-1.53）或 ASB（调整后的 HR = 1.21；95% CI：1.05-1.40）的参与者 AF 风险增加。用 NJ 代替 1 个单位/天的 SSB 与新发 AF 的风险降低 9%（调整后的 HR = 0.91；95% CI：0.83-0.99）相关，而用 ASB 代替 SSB 与新发 AF 无显著相关性（调整后的 HR = 0.97；95% CI：0.89-1.06）。
SSB 和 ASB 的摄入量均与新发 AF 呈线性正相关，而 NJ 摄入量与糖尿病前期或糖尿病患者的 AF 无显著相关性。用 NJ 等量替代 SSB 摄入与 AF 风险降低相关，而用 ASB 替代 SSB 则不相关。
