Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
Functional Science Laboratory, West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, Chengdu, Sichuan 610041, China.
ACS Appl Mater Interfaces. 2024 Aug 28;16(34):44361-44375. doi: 10.1021/acsami.4c07043. Epub 2024 Aug 20.
The global spread of infectious diseases caused by pathogenic bacteria significantly poses public health concerns, and methods for sensitive, selective, and facile diagnosis of bacteria can efficiently prevent deterioration and further spreading of the infections. The advent of nanozymes has broadened the spectrum of alternatives for diagnosing bacterial infections. Compared to natural enzymes, nanozymes exhibit the same enzymatic characteristics but offer greater economic efficiency, enhanced durability, and adjustable dimensions. The importance of early diagnosis of bacterial infection and conventional diagnostic approaches is introduced. Subsequently, the review elucidates the definition, properties, and catalytic mechanism of nanozymes. Eventually, the detailed application of nanozymes in detecting bacteria is explored, highlighting their utilization as biosensors that allow for accelerated and highly sensitive identification of bacterial infections and reflecting on the potential of nanozyme-based bacterial detection as a point-of-care testing (POCT) tool. A brief summary of obstacles and future perspectives in this field is presented at the conclusion of this review.
致病性细菌引起的传染病在全球范围内传播，严重威胁着公众健康，因此能够灵敏、选择性和便捷地诊断细菌的方法可以有效地防止感染的恶化和进一步传播。纳米酶的出现拓宽了诊断细菌感染的替代方法的范围。与天然酶相比，纳米酶具有相同的酶学特性，但具有更高的经济性、更强的耐用性和可调节的尺寸。本文首先介绍了细菌感染早期诊断和传统诊断方法的重要性。随后，本文阐述了纳米酶的定义、性质和催化机制。最后，详细探讨了纳米酶在细菌检测中的应用，强调了它们作为生物传感器的利用，能够加速和高度敏感地识别细菌感染，并反映了基于纳米酶的细菌检测作为即时检测（POCT）工具的潜力。本文在总结部分简要概述了该领域的障碍和未来展望。
