School of Biological and Chemical Sciences, Galway, H91TK33, Ireland.
SSPC, SFI Research Centre for Pharmaceuticals, Galway, H91TK33, Ireland.
Chem Soc Rev. 2024 Sep 30;53(19):9428-9445. doi: 10.1039/d4cs00642a.
Glycan recognition by lectins mediates important biological events. This Tutorial Review aims to introduce lectin-ligand interactions and show how these molecular recognition events inspire innovations such as: (i) glycomimetic ligands; (ii) multivalent ligand agonists/antagonists; (iii) ligands for precision delivery of therapies to cells, where therapies include vaccines, siRNA and LYTACs (iv) development of diagnostics. A small number of case studies are selected to demonstrate principles for development of new ligands for applications inspired by knowledge of natural glycan ligand structure and function.
糖链识别由凝集素介导，这一过程参与了许多重要的生物学事件。本综述旨在介绍凝集素-配体相互作用，并展示这些分子识别事件如何激发创新，例如：（i）糖模拟配体；（ii）多价配体激动剂/拮抗剂；（iii）用于将治疗药物精确递送至细胞的配体，其中治疗药物包括疫苗、siRNA 和 LYTACs；（iv）诊断试剂的开发。选择了少数案例研究来演示基于对天然糖链配体结构和功能的了解，为受启发而开发新配体的应用的原则。
