Park Jun, Na Chong-Sam
Department of Animal Biotechnology, Jeonbuk National University, Jeonju 54896, Korea.
J Anim Sci Technol. 2024 Jul;66(4):702-716. doi: 10.5187/jast.2024.e104. Epub 2024 Jul 31.
The objective of this study was to identify genomic regions and candidate genes associated with productive traits using a total of 37,099 productive records and 6,683 single nucleotide polymorphism (SNP) data obtained from five Great-Grand-Parents (GGP) farms in Landrace. The estimated of heritabilities for days to 105 kg (AGE), average daily gain (ADG), backfat thickness (BF), and eye muscle area (EMA) were 0.49, 0.49, 0.56, and 0.23, respectively. We identified a genetic window that explained 2.05%-2.34% for each trait of the total genetic variance. We observed a clear partitioning of the four traits into two groups, and the most significant genomic region for AGE and ADG were located on the chromosome (SSC) 1, while BF and EMA were located on SSC 2. We conducted Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG), which revealed results in three biological processes, four cellular component, three molecular function, and six KEGG pathway. Significant SNPs can be used as markers for quantitative trait loci (QTL) investigation and genomic selection (GS) for productive traits in Landrace pig.
本研究的目的是利用从五个长白猪曾祖代（GGP）猪场获得的总共37,099条生产记录和6,683个单核苷酸多态性（SNP）数据，确定与生产性状相关的基因组区域和候选基因。105千克体重日龄（AGE）、平均日增重（ADG）、背膘厚度（BF）和眼肌面积（EMA）的遗传力估计值分别为0.49、0.49、0.56和0.23。我们确定了一个遗传窗口，其对每个性状的总遗传方差解释率为2.05%-2.34%。我们观察到这四个性状明显分为两组，AGE和ADG最显著的基因组区域位于1号染色体（SSC）上，而BF和EMA位于SSC 2上。我们进行了基因本体论（GO）和京都基因与基因组百科全书（KEGG）分析，结果揭示了三个生物学过程、四个细胞成分、三个分子功能和六个KEGG通路。显著的SNP可作为长白猪生产性状数量性状位点（QTL）研究和基因组选择（GS）的标记。
