Guo Wen, Liu Wenqiong, Wang Junqing, Fan Xinran
Shandong University of Traditional Chinese Medicine, Jinan, 250000, China.
Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, 250000, China.
Heliyon. 2024 Jul 26;10(15):e35063. doi: 10.1016/j.heliyon.2024.e35063. eCollection 2024 Aug 15.
Cervical cancer is a serious threat to women's health. Extracellular vesicles exist in most body fluids for communication between organisms, having different effects on the occurrence, development, angiogenesis, and metastasis of cervical cancer, and are expected to become new targets for treatment. Macrophages are natural immune systems closely linked to the development of cervical cancer. In recent years, an increasing number of studies have confirmed the role of extracellular vesicles and macrophages in the gynecologic tumor environment. This article reviews the mechanism of action and application prospects of extracellular vesicles and macrophages in the cervical cancer microenvironment. In addition, the relationship between extracellular vesicles and macrophages from different sources is described, which provides ideas for the diagnosis and treatment of cervical cancer.
宫颈癌对女性健康构成严重威胁。细胞外囊泡存在于大多数体液中，用于生物体之间的通讯，对宫颈癌的发生、发展、血管生成和转移具有不同影响，有望成为新的治疗靶点。巨噬细胞是与宫颈癌发展密切相关的天然免疫系统。近年来，越来越多的研究证实了细胞外囊泡和巨噬细胞在妇科肿瘤微环境中的作用。本文综述了细胞外囊泡和巨噬细胞在宫颈癌微环境中的作用机制及应用前景。此外，还描述了不同来源的细胞外囊泡与巨噬细胞之间的关系，为宫颈癌的诊断和治疗提供思路。
