Translational Extracellular Vesicles in Obstetrics and Gynae-Oncology Group, University of Queensland Centre for Clinical Research, Faculty of Medicine, Royal Brisbane and Women's Hospital, The University of Queensland, Brisbane, QLD 4029, Australia.
Department of Clinical Biochemistry, Aalborg University Hospital, Aalborg, Denmark.
Cytokine Growth Factor Rev. 2023 Oct;73:52-68. doi: 10.1016/j.cytogfr.2023.06.004. Epub 2023 Jul 1.
Extracellular vesicles (EVs) are messengers that carry information in the form of proteins, lipids, and nucleic acids and are not only essential for intercellular communication but also play a critical role in the progression of various pathologies, including ovarian cancer. There has been recent substantial research characterising EV cargo, specifically, the lipid profile of EVs. Lipids are involved in formation and cargo sorting of EVs, their release and cellular uptake. Numerous lipidomic studies demonstrated the enrichment of specific classes of lipids in EVs derived from cancer cells suggesting that the EV associated lipids can potentially be employed as minimally invasive biomarkers for early diagnosis of various malignancies, including ovarian cancer. In this review, we aim to provide a general overview of the heterogeneity of EV, biogenesis, their lipid content, and function in cancer progression focussing on ovarian cancer.
细胞外囊泡 (EVs) 是一种携带蛋白质、脂质和核酸等信息的信使，不仅在细胞间通讯中起着至关重要的作用，而且在各种病理过程的发展中也起着关键作用，包括卵巢癌。最近有大量研究对 EV 货物进行了描述，特别是 EV 的脂质谱。脂质参与 EV 的形成和货物分拣、释放和细胞摄取。许多脂质组学研究表明，源自癌细胞的 EV 中特定脂质类别的富集，这表明 EV 相关脂质可能可以作为微创生物标志物，用于早期诊断各种恶性肿瘤，包括卵巢癌。在这篇综述中，我们旨在提供 EV 的异质性、生物发生、其脂质含量以及在癌症进展中的功能的概述，重点是卵巢癌。
