School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai, China.
School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai, China.
Talanta. 2024 Dec 1;280:126717. doi: 10.1016/j.talanta.2024.126717. Epub 2024 Aug 15.
The presence of malignant tumors poses a significant threat to people's life and well-being. As biochemical parameters indicate the occurrence and development of tumors, tumor markers play a pivotal role in early cancer detection, treatment, prognosis, efficient monitoring, and other aspects. Surface-enhanced Raman scattering (SERS) is considered a potent tool for the detection of tumor markers owing to its exceptional advantages encompassing high sensitivity, superior selectivity, rapid analysis speed, and photobleaching resistance nature. This review aims to provide a comprehensive understanding of SERS applications in the detection of tumor markers. Firstly, we introduce the SERS enhancement mechanism, classification of active substrates, and SERS detection techniques. Secondly, the latest research progress of in vitro SERS detection of different types of tumor markers in body fluids and the application of SERS imaging in biomedical imaging are highlighted in sections of the review. Finally, according to the current status of SERS detection of tumor markers, the challenges and problems of SERS in biomedical detection are discussed, and insights into future developments in SERS are offered.
恶性肿瘤的存在对人们的生命和健康构成了重大威胁。由于生化参数表明了肿瘤的发生和发展，肿瘤标志物在癌症的早期检测、治疗、预后、有效监测等方面发挥着关键作用。表面增强拉曼散射（SERS）由于其具有高灵敏度、高选择性、快速分析速度和抗光漂白等优异优势，被认为是一种用于检测肿瘤标志物的有效工具。本综述旨在全面了解 SERS 在肿瘤标志物检测中的应用。首先，我们介绍了 SERS 的增强机制、活性基底的分类和 SERS 检测技术。其次，我们重点介绍了 SERS 技术在不同类型体液中肿瘤标志物的体外检测和 SERS 成像在生物医学成像中的最新研究进展。最后，根据目前肿瘤标志物的 SERS 检测现状，讨论了 SERS 在生物医学检测中面临的挑战和问题，并对 SERS 的未来发展进行了展望。
