van Egmond Lieve T, Meth Elisa M S, Engström Joachim, Ilemosoglou Maria, Keller Jasmin Annica, Vogel Heike, Benedict Christian
Department of Surgical Sciences, Sleep Science Laboratory, Uppsala University, Uppsala, Sweden.
Department of Pharmaceutical Biosciences, Molecular Neuropharmacology, Uppsala University, Uppsala, Sweden.
Obesity (Silver Spring). 2023 Mar;31(3):635-641. doi: 10.1002/oby.23616. Epub 2022 Nov 20.
This study investigated whether blood concentrations of leptin, ghrelin, and adiponectin are affected by acute total sleep deprivation in a sex- and weight-specific manner.
A total of 44 participants (mean age 24.9 years; 20 women; 19 with obesity) participated in a crossover design, including one night of sleep deprivation and one night of sleep in the laboratory. After each night, fasting blood was collected.
After sleep deprivation, fasting levels of leptin were lower (mean [SE], vs. sleep: 17.3 [2.6] vs. 18.6 [2.8] ng/mL), whereas those of ghrelin and adiponectin were higher (839.4 [77.5] vs. 741.4 [63.2] pg/mL and 7.5 [0.6] vs. 6.8 [0.6] μg/mL, respectively; all p < 0.05). The changes in leptin and adiponectin following sleep loss were more pronounced among women. Furthermore, the ghrelin increase was stronger among those with obesity after sleep loss. Finally, the sleep loss-induced increase in adiponectin was more marked among normal-weight participants.
Acute sleep deprivation reduces blood concentrations of the satiety hormone leptin. With increased blood concentrations of ghrelin and adiponectin, such endocrine changes may facilitate weight gain if persisting over extended periods of sleep loss. The observed sex- and weight-specific differences in leptin, ghrelin, and adiponectin call for further investigation.
本研究调查了瘦素、胃饥饿素和脂联素的血浓度是否会受到急性完全睡眠剥夺的性别和体重特异性影响。
共有44名参与者（平均年龄24.9岁；20名女性；19名肥胖者）参与了一项交叉设计，包括在实验室进行一晚的睡眠剥夺和一晚的睡眠。每晚过后，采集空腹血样。
睡眠剥夺后，瘦素的空腹水平较低（平均值[标准误]，与睡眠时相比：17.3[2.6]对18.6[2.8]纳克/毫升），而胃饥饿素和脂联素的空腹水平较高（分别为839.4[77.5]对741.4[63.2]皮克/毫升和7.5[0.6]对6.8[0.6]微克/毫升；所有p<0.05）。睡眠缺失后瘦素和脂联素的变化在女性中更为明显。此外，睡眠缺失后肥胖者的胃饥饿素增加更为显著。最后，体重正常的参与者中，睡眠缺失引起的脂联素增加更为明显。
急性睡眠剥夺会降低饱腹感激素瘦素的血浓度。随着胃饥饿素和脂联素血浓度的升高，如果这种内分泌变化在长期睡眠缺失中持续存在，可能会促进体重增加。观察到的瘦素、胃饥饿素和脂联素在性别和体重上的差异需要进一步研究。
