Yan Zi-Wei, Liu Ying-Nan, Xu Qian, Yuan Yuan
Tumor Etiology and Screening Department of Cancer Institute and General Surgery, The First Hospital of China Medical University, Shenyang 110001, Liaoning Province, China.
Key Laboratory of Cancer Etiology and Prevention in Liaoning Education Department, The First Hospital of China Medical University, Shenyang 110001, Liaoning Province, China.
World J Gastrointest Oncol. 2024 Aug 15;16(8):3687-3704. doi: 10.4251/wjgo.v16.i8.3687.
Depression is strongly associated with colorectal cancer (CRC). Few bibliometric analyses have systematically summarized the research focus and recent progress in this field.
To determine the research status and hotspots by bibliometric analysis of relevant publications on the relationship between CRC and depression.
Articles on depression in CRC patients were collected from the Web of Science Core Collection. CiteSpace and VOSviewer software were used to visualize bibliometric networks.
From 2001 to 2022, , the United States, Tilburg University, and Mols were the most productive and influential journal, country, institution, and author name. Co-occurrence cluster analysis of keywords placed quality of life, anxiety, and psychological stress in the center of the visual network diagram. Further clustering was performed for the clusters with studies of the relevant mechanism of action, which showed that: (1) Cytokines have a role essential for the occurrence and development of depressive disorders in CRC; (2) MicroRNAs have a role essential for the development of depressive disorders in CRC; (3) Some anticancer drugs have pro-depressant activity; and (4) Selective serotonin reuptake inhibitors have both antitumor and antidepressant activity.
Life quality and psychological nursing of the cancer population were key topics. The roles of cytokines and microRNAs, the pro-depression activity of anticancer drugs and their antitumor properties deserve in-depth study.
抑郁症与结直肠癌（CRC）密切相关。很少有文献计量分析系统地总结该领域的研究重点和最新进展。
通过对CRC与抑郁症关系的相关出版物进行文献计量分析，确定研究现状和热点。
从科学网核心合集收集关于CRC患者抑郁症的文章。使用CiteSpace和VOSviewer软件对文献计量网络进行可视化。
2001年至2022年期间，美国、蒂尔堡大学和莫尔斯是产出最多且最具影响力的期刊、国家、机构和作者姓名。关键词共现聚类分析将生活质量、焦虑和心理压力置于可视化网络图的中心。对有关作用机制研究的聚类进行了进一步聚类，结果表明：（1）细胞因子在CRC抑郁症发生发展中起关键作用；（2）微小RNA在CRC抑郁症发展中起关键作用；（3）一些抗癌药物具有促抑郁活性；（4）选择性5-羟色胺再摄取抑制剂具有抗肿瘤和抗抑郁活性。
癌症人群的生活质量和心理护理是关键主题。细胞因子和微小RNA的作用、抗癌药物的促抑郁活性及其抗肿瘤特性值得深入研究。
