West China School of Medicine, Sichuan University, Chengdu, China.
Gastrointestinal Surgery Center of West China Hospital, Sichuan University, Chengdu, China.
Support Care Cancer. 2021 Oct;29(10):5635-5652. doi: 10.1007/s00520-021-06185-x. Epub 2021 Mar 31.
Different non-pharmacological interventions have been considered and applied to patients with colorectal cancer to improve their quality of life and distress symptoms; however, there is little evidence comparing the effectiveness of these strategies. This review aimed at assessing the effect of non-pharmacological interventions on quality of life, anxiety, and depression scores among patients with colorectal cancer.
A systematic search for articles published until August 1, 2020, in the English language was performed in Medline, EMBASE, Web of Science, and the Cochrane Library; the reference lists of eligible articles were scanned for other potentially eligible publications. A meta-analysis was performed using random-effects models to estimate pooled effect sizes.
Twenty studies were included, representing a total of 3438 patients with colorectal cancer. Non-pharmacological interventions were associated with a significant reduction in anxiety (standardized mean difference [SMD] = - 0.157; 95% confidence interval [CI], - 0.312-[- 0.002]) and depression (SMD = - 0.207; 95% CI, - 0.390-[- 0.024]) scores during 5-8 months of follow-up. Subgroup analyses revealed that interventions delivered face-to-face improved patients' quality of life during 1-4 months of follow-up. Moreover, interventions delivered face-to-face but without a behavioral component were associated with improved anxiety scores, whereas interventions with a behavioral component improved the depression scores during 5-8 months of follow-up.
Non-pharmacological interventions were associated with reduced anxiety and depression scores, whereas interventions delivered face-to-face were associated with improved quality of life scores in patients with colorectal cancer. Given the few studies and patients included in this meta-analysis, these conclusions should be interpreted with caution.
不同的非药物干预措施已被考虑并应用于结直肠癌患者，以改善其生活质量和痛苦症状；然而，很少有证据比较这些策略的有效性。本综述旨在评估非药物干预措施对结直肠癌患者生活质量、焦虑和抑郁评分的影响。
系统检索截至 2020 年 8 月 1 日在 Medline、EMBASE、Web of Science 和 Cochrane Library 发表的英文文献，扫描纳入文献的参考文献以获取其他潜在的合格文献。使用随机效应模型进行荟萃分析，以估计汇总效应大小。
共纳入 20 项研究，共纳入 3438 例结直肠癌患者。非药物干预措施与焦虑评分显著降低相关（标准化均数差 [SMD] = -0.157；95%置信区间 [CI]，-0.312-[-0.002]）和抑郁评分（SMD = -0.207；95%CI，-0.390-[-0.024]）在 5-8 个月的随访期间。亚组分析显示，面对面的干预措施在 1-4 个月的随访期间改善了患者的生活质量。此外，面对面但没有行为成分的干预措施与焦虑评分的改善相关，而具有行为成分的干预措施与 5-8 个月随访期间的抑郁评分改善相关。
非药物干预措施与降低焦虑和抑郁评分相关，而面对面的干预措施与结直肠癌患者的生活质量评分提高相关。鉴于本荟萃分析纳入的研究和患者数量较少，这些结论应谨慎解释。
