Deng Qianyi, Wong Hai Ming, Peng Simin
Paediatric Dentistry and Orthodontics, Faculty of Dentistry, The University of Hong Kong, Hong Kong SAR, China.
Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat-Sen University, Guangzhou, China.
Oral Dis. 2024 Aug 22. doi: 10.1111/odi.15111.
To investigate the effect of adiposity status, salivary physicochemical parameters, and inflammatory biomarkers on the salivary abundance of the two main cariogenic bacteria Streptococcus mutans and Streptococcus sobrinus among Hong Kong adolescents.
This study included 180 adolescents aged 12-15 years from Hong Kong local secondary schools. Anthropometric measurements and oral health examinations were performed. Saliva samples were collected to measure salivary physicochemical parameters, protein biomarker levels, and salivary abundance of Streptococcus mutans, Streptococcus sobrinus, and total bacteria.
Adolescents with general overweight/obesity or central obesity had significantly higher salivary Streptococcus mutans abundance and total bacterial load, lower stimulated salivary flow rate, and lower secretory phospholipase A group IIA levels than the lean controls. Adolescents with general overweight/obesity (OR = 3.33; 95% CI: 1.28-8.65) and those with central obesity (OR = 2.47; 95% CI: 1.02-6.00) had a significantly higher chance of having high salivary abundance of Streptococcus mutans than the lean controls after adjusting for confounders, with a similar detection rate of salivary Streptococcus sobrinus.
General overweight or obesity and central obesity were associated with a high salivary abundance of Streptococcus mutans but had no significant effect on salivary Streptococcus sobrinus.
探讨肥胖状况、唾液理化参数及炎症生物标志物对香港青少年唾液中两种主要致龋菌——变形链球菌和远缘链球菌数量的影响。
本研究纳入了180名来自香港本地中学的12至15岁青少年。进行了人体测量和口腔健康检查。收集唾液样本以测量唾液理化参数、蛋白质生物标志物水平，以及变形链球菌、远缘链球菌和总细菌的唾液数量。
与体重正常的对照组相比，一般超重/肥胖或中心性肥胖的青少年唾液中变形链球菌数量和总细菌载量显著更高，刺激唾液流速更低，分泌型磷脂酶A IIA水平更低。在调整混杂因素后，一般超重/肥胖的青少年（比值比[OR]=3.33；95%置信区间[CI]：1.28 - 8.65）和中心性肥胖的青少年（OR = 2.47；95% CI：1.02 - 6.00）唾液中变形链球菌数量高的可能性显著高于体重正常的对照组，远缘链球菌的唾液检出率相似。
一般超重或肥胖以及中心性肥胖与唾液中变形链球菌数量高有关，但对唾液中远缘链球菌没有显著影响。
