Department of Physiology and Biophysics, The University of Illinois at Chicago College of Medicine, Chicago, IL 60612, USA.
The Center for Cardiovascular Research, The University of Illinois at Chicago College of Medicine, Chicago, IL 60612, USA.
Aging (Albany NY). 2024 Aug 21;16(17):12105-12107. doi: 10.18632/aging.206097.
Nuclear envelope proteins have recently gained traction as novel regulators of endothelial and vascular function. Nuclear pore complexes (NPCs) stand as one of the largest protein complexes found at the nuclear envelope yet the role of component NPC proteins (i.e., nucleoporins) in vascular health remains unclear. In the issue of Aging Cell, Nguyen et al. (2024) identify Nucleoporin93, a major structural protein of the NPC, as an indispensable player in endothelial protection. This discovery raises the possibility that endothelial NPCs are susceptible to risk factors for consequent vascular disease.
核膜蛋白最近作为内皮细胞和血管功能的新型调节因子引起了关注。核孔复合物（NPC）是核膜上发现的最大的蛋白质复合物之一，但 NPC 成分蛋白（即核孔蛋白）在血管健康中的作用尚不清楚。在《Aging Cell》杂志上，Nguyen 等人（2024 年）发现核孔蛋白 93（NPC 的主要结构蛋白）是内皮细胞保护不可或缺的参与者。这一发现提示内皮细胞 NPC 可能容易受到血管疾病风险因素的影响。
