Rylance P B, Brincat M, Lafferty K, De Trafford J C, Brincat S, Parsons V, Studd J W
Br Med J (Clin Res Ed). 1985 Jan 5;290(6461):13-4. doi: 10.1136/bmj.290.6461.13.
In a placebo controlled, double blind crossover study natural progesterone was given by mouth, in increasing doses, to six men and four postmenopausal women with mild to moderate hypertension who were not receiving any other antihypertensive drugs. When compared with values recorded before treatment and during administration of placebo progesterone caused a significant reduction in blood pressure, suggesting that progesterone has an antihypertensive action rather than a hypertensive one as has been previously thought. This possible protective effect of progesterone should be investigated further.
在一项安慰剂对照、双盲交叉研究中，对6名男性和4名绝经后轻度至中度高血压女性口服天然孕酮，剂量逐渐增加，这些人未服用任何其他降压药物。与治疗前和服用安慰剂期间记录的值相比，孕酮使血压显著降低，这表明孕酮具有降压作用，而非如之前所认为的升压作用。孕酮这种可能的保护作用应进一步研究。
