Küçük Beyza Nur, Yilmaz Eylul Gulsen, Aslan Yusuf, Erdem Özgecan, Inci Fatih
UNAM─National Nanotechnology Research Center, Bilkent University, 06800 Ankara, Turkey.
Institute of Materials Science and Nanotechnology, Bilkent University, 06800 Ankara, Turkey.
ACS Appl Bio Mater. 2024 Sep 16;7(9):5841-5860. doi: 10.1021/acsabm.4c00782. Epub 2024 Aug 23.
In the relentless pursuit of innovative diagnostic tools for cancer, this review illuminates the cutting-edge realm of extracellular vesicles (EVs) and their biomolecular cargo detection through advanced optical biosensing techniques with a primary emphasis on their significance in cancer diagnosis. From the sophisticated domain of nanomaterials to the precision of surface plasmon resonance, we herein examine the diverse universe of optical biosensors, emphasizing their specified applications in cancer diagnosis. Exploring and understanding the details of EVs, we present innovative applications of enhancing and blending signals, going beyond the limits to sharpen our ability to sense and distinguish with greater sensitivity and specificity. Our special focus on cancer diagnosis underscores the transformative potential of optical biosensors in early detection and personalized medicine. This review aims to help guide researchers, clinicians, and enthusiasts into the captivating domain where light meets cellular secrets, creating innovative opportunities in cancer diagnostics.
在对癌症创新诊断工具的不懈追求中，本综述阐明了细胞外囊泡（EVs）的前沿领域以及通过先进光学生物传感技术对其生物分子货物的检测，主要强调它们在癌症诊断中的重要性。从复杂的纳米材料领域到表面等离子体共振的精确性，我们在此审视光学生物传感器的多样世界，强调它们在癌症诊断中的特定应用。通过探索和理解EVs的细节，我们展示了增强和混合信号的创新应用，突破局限以提高我们更灵敏、更特异的传感和区分能力。我们对癌症诊断的特别关注突出了光学生物传感器在早期检测和个性化医疗中的变革潜力。本综述旨在帮助引导研究人员、临床医生和爱好者进入光与细胞秘密相遇的迷人领域，在癌症诊断中创造创新机会。
